NADPH oxidase-mediated generation of reactive oxygen species: A new mechanism for X-ray-induced HeLa cell death

文献类型： 外文期刊

第一作者： Liu, Qing

作者： Liu, Qing;Zhang, Hong;Liu, Qing;Zhang, Hong;He, Xiaoqing;Liu, Yongsheng;Du, Bingbing;Wang, Xiaoyan;Zhang, Weisheng;Jia, Pengfei;Dong, Jingmei;Ma, Jianxiu;Wang, Xiaohu;Li, Sha

作者机构：

关键词： NADPH oxidase;New mechanism;X-ray irradiation;HeLa cell death

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN： 0006-291X

年卷期： 2008 年 377 卷 3 期

页码：

收录情况： SCI

摘要： Oxidative damage is an important mechanism in X-ray-induced cell death. Radiolysis of water molecules is a source of reactive oxygen species (ROS) that contribute to X-ray-induced cell death. In this study, we showed by ROS detection and a cell survival assay that NADPH oxidase has a very important role in X-ray-induced cell death. Under X-ray irradiation, the upregulation of the expression of NADPH oxidase membrane Subunit gp91(phox) was dose-dependent. Meanwhile, the cytoplasmic subunit p47(phox) was translocated to the cell membrane and localized with p22(phox) and gp91(phox) to form reactive NADPH oxidase. Our data Suggest, for the first time, that NADPH oxidase-mediated generation of ROS is an important contributor to X-ray-induced cell death. This suggests a new target for combined gene transfer and radiotherapy. (C) 2008 Elsevier Inc. All rights reserved.

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