Molecular characterization and expression pattern of the porcine STARS, a striated muscle-specific expressed gene

文献类型： 外文期刊

第一作者： Peng, Y. B.

作者： Peng, Y. B.;Guan, H. P.;Fan, B.;Zhao, S. H.;Xu, X. W.;Li, K.;Zhu, M. J.;Liu, B.;Li, K.;Yerle, M.

作者机构：

关键词： sequence analysis;physical mapping;polymorphism;pig;STARS

期刊名称：BIOCHEMICAL GENETICS （ 影响因子：1.89； 五年影响因子：1.959 ）

ISSN： 0006-2928

年卷期： 2008 年 46 卷 9-10 期

页码：

收录情况： SCI

摘要： STARS (striated muscle activator of Rho signaling) promotes the nuclear localization of MRTFs and mediates SRF transcription, which provides a potential muscle-specific mechanism for linking changes in the actin cytoskeleton structure with muscle gene expression. In this study, the full-length cDNA of the porcine STARS was cloned. The open reading frame of this gene contains 1,155 bp and encodes a protein of 384 amino acids, which is 79, 73, and 77% identical with human, mouse, and rat STARS genes, respectively. RT-PCR revealed that STARS is specifically expressed in heart and skeletal muscles. STARS is also distinctly different in different muscle developmental stages. The result indicates that its expression increased gradually from 33 dpc (days postcoitum) to postnatal muscles, and peaked 28 days postnatal. The porcine STARS was mapped to SSC4p13 using the somatic cell hybrid panel and the radiation hybrid panel IMpRH (LOD score 11.98). The data show that STARS is closely linked to marker SW871. A T/G single nucleotide polymorphism in the coding sequence, detected as Bsh1236I PCR-RFLP, displays allele frequency differences in six pig breeds.

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