Enhancement by IL-18 of the protective effect of a Schistosoma japonicum 26 kDa GST plasmid DNA vaccine in mice
文献类型: 外文期刊
第一作者: Wei, Feng
作者: Wei, Feng;Liu, Quan;Gao, Shengyan;Shang, Limin;Zhai, Yujia;Men, Jingtao;Jiang, Li;Xia, Zhiping;Wei, Feng;Gao, Shengyan;Zhu, Xing-Quan;Fu, Zhiqiang;Shi, Yaojun
作者机构:
关键词: Schistosoma japonicum;Sj26GST;IL-18;DNA vaccine;mice
期刊名称:VACCINE ( 影响因子:3.641; 五年影响因子:3.816 )
ISSN: 0264-410X
年卷期: 2008 年 26 卷 33 期
页码:
收录情况: SCI
摘要: Two recombinant plasmids pVAX/Sj26GST and pVAX/mIL-18 containing Schistosoma japonicum 26 kDa GST and murine IL-18 were evaluated for their ability to protect mice against S. japonicum challenge. Mice were given 2 intramuscular immunizations 3 weeks apart, and challenged with S. japonicum cercariae 4 weeks later. Adult worm and egg burdens were determined 48 days post-challenge. All animals vaccinated with pVAX/Sj26GST alone or with pVAX/mIL-18 developed specific anti-SWAP (soluble worm antigen preparation) ELISA antibody and splenocyte proliferation response. Co-injection of pVAX/mIL-18 significantly increased the production of IFN-gamma and IL-12, indicating that IL-18 enhances the Th1-dominant immune response. Challenge experiments showed that worms were reduced in the pVAX/Sj26GST group by 30.1% and by 49.4% in animals given pVAX/mIL-18 additionally. Corresponding hepatic and fecal egg reductions were 44.8% and 53.0%, and 50.6% and 56.6%, respectively. These results indicate that IL-18 may be an effective adjuvant for a schistosomiasis vaccine. (C) 2008 Elsevier Ltd. All rights reserved.
分类号:
- 相关文献
作者其他论文 更多>>
-
First Report and Genetic Characterization of Border Disease Virus in Sheep from Hulunbuir, Northeastern China
作者:Yuan, Yongxu;Li, Liang;Liu, Ziyan;Liu, Quan;Wang, Zedong;Yuan, Yongxu;Liu, Ziyan;Xu, Wenbo;Liu, Ning;Sui, Liyan;Zhao, Yinghua;Liu, Quan;Wang, Zedong;Yang, Xing;Wang, Wei
关键词:
-
BmC/EBPZ gene is essential for the larval growth and development of silkworm, Bombyx mori
作者:Mei, Xinglin;Huang, Tianchen;Liu, Weibin;Jiang, Li;Zhong, Shanshan;Shen, Dongxu;Qiao, Peitong;Zhao, Qiaoling;Chen, Anli;Shen, Dongxu;Zhao, Qiaoling
关键词:Bombyx mori; BmC/EBPZ; GMS mutant; small larvae; positional cloning; CRISPR/Cas9
-
Novel Environmentally Friendly RNAi Biopesticides: Targeting V-ATPase in Holotrichia parallela Larvae Using Layered Double Hydroxide Nanocomplexes
作者:Jiang, Li;Wang, Qian;Kang, Zhan-hai;Wen, Jing-xin;Yang, Yu-bo;Lu, Xiu-jun;Guo, Wei;Zhao, Dan;Guo, Wei
关键词:RNAi; nanocomplex; eco-friendly; biopesticides
-
Compensatory effects of other olfactory genes after CRISPR/cas9 editing of BmOR56 in silkworm, Bombyx mori
作者:Jiang, Li;Li, Cong;Shen, Dongxu;Qian, Heying;Zhao, Qiaoling;Shen, Dongxu;Qian, Heying;Zhao, Qiaoling;Wang, Pingyang;Chen, Anli
关键词:BmOR56; Molecular docking; CRISPR/Cas9; Feeding habits; Transcriptome
-
AMEP412 as a potent antifungal agent against rice blast fungus Magnaporthe oryzae in vivo and in vitro
作者:Yang, Junyan;Guo, Meijun;Liu, Quan;Yang, Junyan;Wang, Quan;Guo, Meijun;Liu, Quan
关键词:Rice blast; Magnaporthe oryzae; AMEP412 protein; antifungal activity; biofungicide
-
Arbuscular mycorrhizal fungi offset NH3 emissions in temperate meadow soil under simulated warming and nitrogen deposition
作者:Cui, Nan;Tian, Yibo;Shi, Lianxuan;Guo, Jixun;Sun, Mingzhou;Zhang, Tao;Veresoglou, Stavros;Guo, Rui;Zhang, Lei;Jiang, Li;Kang, Furong;Yuan, Weizhe;Hou, Dan
关键词:Arbuscular mycorrhizal (AM) fungi; Ammonia emission; Soil ammonium nitrogen; Soil pH; Functional gene
-
R3 strain and Fe-Mn modified biochar reduce Cd absorption capacity of roots and available Cd content of soil by affecting rice rhizosphere and endosphere key flora
作者:Tian, Yunhe;Chen, Xinyu;He, Jing;Tian, Meijie;Hu, Ruiwen;Fu, Zhiqiang;Yi, Zhenxie;Li, Juan;Li, Peng;Zheng, Zhongyi;Hu, Ruiwen
关键词:Rice; Cd content; Bacterial community; Soil Cd species; Soil nutrient; Contaminated soil remediation