Enhancement by IL-18 of the protective effect of a Schistosoma japonicum 26 kDa GST plasmid DNA vaccine in mice

文献类型： 外文期刊

第一作者： Wei, Feng

作者： Wei, Feng;Liu, Quan;Gao, Shengyan;Shang, Limin;Zhai, Yujia;Men, Jingtao;Jiang, Li;Xia, Zhiping;Wei, Feng;Gao, Shengyan;Zhu, Xing-Quan;Fu, Zhiqiang;Shi, Yaojun

作者机构：

关键词： Schistosoma japonicum;Sj26GST;IL-18;DNA vaccine;mice

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN： 0264-410X

年卷期： 2008 年 26 卷 33 期

页码：

收录情况： SCI

摘要： Two recombinant plasmids pVAX/Sj26GST and pVAX/mIL-18 containing Schistosoma japonicum 26 kDa GST and murine IL-18 were evaluated for their ability to protect mice against S. japonicum challenge. Mice were given 2 intramuscular immunizations 3 weeks apart, and challenged with S. japonicum cercariae 4 weeks later. Adult worm and egg burdens were determined 48 days post-challenge. All animals vaccinated with pVAX/Sj26GST alone or with pVAX/mIL-18 developed specific anti-SWAP (soluble worm antigen preparation) ELISA antibody and splenocyte proliferation response. Co-injection of pVAX/mIL-18 significantly increased the production of IFN-gamma and IL-12, indicating that IL-18 enhances the Th1-dominant immune response. Challenge experiments showed that worms were reduced in the pVAX/Sj26GST group by 30.1% and by 49.4% in animals given pVAX/mIL-18 additionally. Corresponding hepatic and fecal egg reductions were 44.8% and 53.0%, and 50.6% and 56.6%, respectively. These results indicate that IL-18 may be an effective adjuvant for a schistosomiasis vaccine. (C) 2008 Elsevier Ltd. All rights reserved.

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