LC-Tandem-MS development and validation for the determination of tegaserod in beagle dog plasma and its application to a pharmacokinetic study

文献类型： 外文期刊

第一作者： Zhang, Shuang-Qing

作者： Zhang, Shuang-Qing;Zhang, Shuang-Qing;Chen, Guo-Hua

作者机构：

关键词： column liquid chromatography-tandem mass spectrometry;pharmacokinetics;dog plasma;tegaserod

期刊名称：CHROMATOGRAPHIA （ 影响因子：2.044； 五年影响因子：1.725 ）

ISSN： 0009-5893

年卷期： 2008 年 67 卷 9-10 期

页码：

收录情况： SCI

摘要： A sensitive and selective liquid chromatography-tandem mass spectrometry method for quantitative determination of tegaserod was developed and validated over the linearity range 1.0-200.0 ng mL(-1) with 0.5 mL of plasma using diphenhydramine as an internal standard. Liquid-liquid extraction using ethyl ether was used to extract the drug and the internal standard from plasma. The mass spectrometer was operated under the selected reaction monitoring mode using the atmospheric pressure chemical ionization technique. The mobile phase consisted of methanol-water-formic acid (80:20:1, v/v/v), at a flow rate of 0.6 mL min(-1). In the positive mode, tegaserod produced a protonated precursor ion at m/z 302 and a corresponding product ion at m/z 173. The internal standard produced a protonated precursor ion at m/z 256 and a corresponding product ion at m/z 167. The intra- and inter-day accuracy at all levels fell in the ranges of 100.72-102.75% and 100.61-105.45%, and the intra- and inter-day precision were in the ranges of 4.20-5.74% and 1.90-4.17%, respectively. The method was successfully applied to a pharmacokinetic study of tegaserod after an oral administration of two kinds of tegaserod preparations to beagle dogs.

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