Pathological changes in masked palm civets experimentally infected by severe acute respiratory syndrome (SARS) coronavirus

文献类型： 外文期刊

第一作者： Xiao, Y.

作者： Xiao, Y.;Meng, Q.;Yin, X.;Guan, Y.;Liu, Y.;Li, C.;Wang, M.;Liu, G.;Tong, T.;Kong, X.;Wu, D.;Xiao, Y.;Meng, Q.;Liu, G.;Tong, T.;Kong, X.;Wu, D.;Wang, L. -F.

作者机构：

关键词： apoptosis;civet;in-situ hybridization;SARS coronavirus

期刊名称：JOURNAL OF COMPARATIVE PATHOLOGY （ 影响因子：1.311； 五年影响因子：1.686 ）

ISSN： 0021-9975

年卷期： 2008 年 138 卷 4 期

页码：

收录情况： SCI

摘要： Masked palm civets are highly susceptible to infection with the severe acute respiratory, syndrome coronavirus (SARS-CoV). Infected animals become less aggressive and develop pyrexia, lethargy and diarrhoea. The present Study describes the spectrum of histopathological charges in the lung, spleen, lymph node, liver, small intestine, kidney and cerebrum of civets infected experimentally with SARS-CoV. In-situ hybridization (ISH) with probes specific for the RNA polymerase gene demonstrated viral RNA in the lung, small intestine and cerebrum only. In-situ labelling was employed in order to demonstrate cellular apoptosis in the cerebrum, but there was no evidence of apoptosis within the myocardium. These results indicate that SARS-CoV causes multi-organ pathology in Civets, similar to that observed in human SARS patients. These parallels suggest that Civets may be Used as an animal model of this infection to gain insight into the pathogenesis of SARS and for evaluation of candidate vaccines and antiviral drugs. (c) 2008 Elsevier Ltd. All rights reserved.

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