Simultaneous determination of nitroimidazole residues in honey samples by high-performance liquid chromatography with ultraviolet detection

文献类型： 外文期刊

第一作者： Zhou, Jinhui

作者： Zhou, Jinhui;Shen, Jianzhong;Xue, Xiaofeng;Zhao, Jing;Li, Yi;Zhang, Jinzhen;Zhang, Suxia

作者机构：

期刊名称：JOURNAL OF AOAC INTERNATIONAL （ 影响因子：1.913； 五年影响因子：1.754 ）

ISSN： 1060-3271

年卷期： 2007 年 90 卷 3 期

页码：

收录情况： SCI

摘要： A rapid and sensitive high-performance liquid chromatography (LC) method was developed for the simultaneous determination of metronidazole (MNZ), dimetridazole (DMZ), ronidazole (RNZ), tinidazole (TNZ), and 2-hydroxymethyl-1-methyl-5-nitroimidazole (HMMNI) in honey. After extraction with ethyl acetate and evaporation, the residue containing the nitroimidazoles was dissolved in ethyl acetate-hexane and subjected to solid-phase extraction cleanup by amine extraction columns. The effluent was evaporated to dryness, and residues were dissolved and determined by LC with an ultraviolet detector set at 315 nm. The limits of detection were 1.0-2.0 ng/g for MNZ, DMZ, RNZ, TNZ, and HMMNI in honey. Average recoveries ranged from 71.5-101.4% in honey fortified at 10, 20, 50, and 100 ng/g. The method was validated for the analysis of real honey samples.

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