New mutations in growth hormone and receptor genes from Chinese Wuzhishan miniature pig

文献类型： 外文期刊

第一作者： Li, J. T.

作者： Li, J. T.;Mu, Y. L.;Zhang, L.;Yang, S. L.;Li, K.;Feng, S. T.

作者机构：

关键词： growth hormone gene;growth hormone receptor gene;WZSP

期刊名称：ACTA AGRICULTURAE SCANDINAVICA SECTION A-ANIMAL SCIENCE （ 影响因子：0.684； ）

ISSN： 0906-4702

年卷期： 2007 年 57 卷 2 期

页码：

收录情况： SCI

摘要： Growth hormone (GH) and receptor genes (GHR) from Chinese Wuzhishan miniature pig (WZSP) were cloned to pGEM-T vector through RT-PCR, which was based on the total RNA obtained from WZSP's pituitary and liver tissues. The results of sequencing showed that the open reading frame of GH gene for WZSP contained 217 amino acids including the signal peptide of 26 amino acids and the coding sequence of GHR gene for WZSP contained 639 amino acids including the signal peptide of 18 amino acids. Two substitutions of amino acids found in the signal peptide of GH gene may affect the transport of GH. Five mutations found in the cytoplasmic domain of GHR may possibly influence GHR signal downstream transduction.

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