Humoral and cellular immune responses to Fasciola gigantica experimental infection in buffaloes

文献类型： 外文期刊

第一作者： Zhang, WY

作者： Zhang, WY;Moreau, E;Yang, BZ;Li, ZQ;Hope, JC;Howard, CJ;Huang, WY;Chauvin, A

作者机构：

关键词： buffaloes;Fasciola gigantica;antibody;antigen;lymphocyte;cytokines

期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）

ISSN： 0034-5288

年卷期： 2006 年 80 卷 3 期

页码：

收录情况： SCI

摘要： Humoral and cellular immune responses to Fasciola gigantica experimental infection in buffaloes were studied. The results showed that 33.4 +/- 9.1% of the infection dose was recovered as adult flukes From infected animals at necropsy. Significant differences of weight gain between infected and non-infected buffaloes was observed at 4 MPI (months post-infection). Anti F gigantica excretory-secretory products (FgESP)-1gG levels increased significantly from 3 WPI (weeks post-infection) and displayed a peak at 13 WPI Western blot indicated that in FgESP six major bands of 11.5, 19.0, 23.4, 29.8, 47.5 and 53.2 kDa were recognized by F. gigantica-infected buffaloes sera after 0 WPI. Eosinophil numbers increased significantly from 3 WPI in F gigantica-infected buffaloes and displayed a peak at 8 WPI. Peripheral blood mononuclear cells (PBMC) proliferation induced by FgESP increased from 2 WPI with a peak at 5 WPI. IFN gamma secretion by FgESP-stirnulated PBMC appeared early from I WPI with three peaks at 2, 5 and 8 WPI, respectively. IL-10 production was observed from 2 WPI with two peaks at 4 and 9 WPI, respectively. Our results suggested that buffaloes were highly susceptible to F gigantica infection, and this susceptibility Could be associated with the late and weak cellular immune response in the early phase of infection and the Th0-like response throughout the infection. (c) 2005 Elsevier Ltd. All rights reserved.

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