Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics

文献类型： 外文期刊

第一作者： Tian, GB

作者： Tian, GB;Zhang, SH;Li, YB;Bu, ZG;Liu, PH;Zhou, JP;Li, CJ;Shi, JZ;Yu, KZ;Chen, HL

作者机构：

关键词： H5N1 influenza;reverse genetics vaccine;chickens;ducks;geese

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2005 年 341 卷 1 期

页码：

收录情况： SCI

摘要： We generated a high-growth H5N1/PR8 virus by plasmid-based reverse genetics. The virulence associated multiple basic amino acids of the HA gene were removed, and the resulting virus is attenuated for chickens and chicken eggs. A formalin-inactivated oil-emulsion vaccine was prepared from this virus. When SPF chickens were inoculated with 0.3 ml of the vaccine, the hemagglutinin-inhibition (HI) antibody became detectable at 1 week post-vaccination (p.v.) and reached a peak of 101log2 at 6 weeks p.v. then slowly declined to 4log2 at 43 weeks p.v. Challenge studies performed at 2, 3 and 43 weeks p.v. indicated that all of the chickens were completely protected from disease signs and death. Ducks and geese were completely protected from highly pathogenic H5N1 virus challenge 3 weeks p.v. The duration of protective inummity in ducks and geese vas investigated by detecting the HI antibody of the field vaccinated birds, and the results indicated that 3 doses of the vaccine inoculation in geese could induce a 34 weeks protection, while 2 doses induced more than 52 weeks protection in ducks. We first reported that an oil-emulsion inactivated vaccine derived from a high-growth H5N1 vaccine induced approximately 10 months of protective immunity in chickens and demonstrated that the oil-emulsion inactivated avian influenza vaccine is immunogenic for geese and ducks. These results provide useful information for the application of vaccines to the control of H5N1 avian influenza in poultry, including chickens and domestic waterfowl. (c) 2005 Elsevier Inc. All rights reserved.

分类号：

  • 相关文献

[1]Seroprevalence of Chlamydophila infection in chickens, ducks, geese and pigeons in Southern China. Zhang, Y. B.,Lin, R. Q.,Wang, X. Q.,Yan, C.,Xu, M. J.,Zhu, X. Q.,Lin, R. Q.,Wang, X. Q.,He, X. H.,Cheng, T.,Wang, Y. N.,Yuan, Z. G.,Yan, C.,Zhu, X. Q.,Zhu, X. Q.. 2011

[2]The quest of influenza A viruses for new hosts. Liu, M,Guan, Y,Peiris, M,He, S,Webby, RJ,Perez, D,Webster, RG. 2003

[3]H5N1 influenza virus-like particle vaccine protects mice from heterologous virus challenge better than whole inactivated virus. Ren, Zhiguang,Qin, Chuan,Xia, Xianzhu,Ren, Zhiguang,Qin, Chuan,Xia, Xianzhu,Ren, Zhiguang,Ji, Xianliang,Meng, Lingnan,Wei, Yurong,Wang, Tiecheng,Feng, Na,Zheng, Xuexing,Wang, Hualei,Li, Nan,Gao, Xiaolong,Zhao, Yongkun,Yang, Songtao,Gao, Yuwei,Xia, Xianzhu,Ji, Xianliang,Meng, Lingnan,Wei, Yurong,Jin, Hongli,Gao, Yuwei,Xia, Xianzhu,Gao, Yuwei,Xia, Xianzhu.

[4]Protective efficacy of commercial Newcastle disease vaccines against challenge of goose origin virulent Newcastle disease virus in geese. Dai, Yabin,Liu, Mei,Li, Wenliang.

[5]The life cycle and pathogenicity of Eimeria fulva Farr, 1953 in domestic goslings. Dai, YB,Liu, M,He, NY,Tao, JP,Liu, XY.

[6]Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia?. Sturm-Ramirez, KM,Hulse-Post, DJ,Govorkova, EA,Humberd, J,Seiler, P,Puthavathana, P,Buranathai, C,Nguyen, TD,Chaisingh, A,Long, HT,Naipospos, TSP,Chen, H,Ellis, TM,Guan, Y,Peiris, JSM,Webster, RG.

[7]Effects of caecectomy on digestibility of crude protein, calcium, phosphorus, neutral detergent fibre and acid detergent fibre in geese. Yang, H. M.,Wang, Z. Y.,Shi, S. R.,Zhu, X. H.,Shi, S. R..

[8]Nutritive Value of Mulberry Leaf Meal and its Effect on the Performance of 35-70-Day-Old Geese. Wang, Chao,Wang, Qigui,Zhou, Xiaorong,Wang, Yangming,Peng, Xiangwei,Yang, Feiyun,Xie, Ming,Kang, Ping.

[9]Effect of dietary conjugated linoleic acid (CLA) on the growth and lipid metabolism of geese and fatty acid composition of their tissues. Zhang, Xu-hui,Wang, Bao-wei,Wang, Lei,Long, Fang-yu,Yang, Zhi-gang,Yu, Shi-hao,Wang, Ya-chao,Wei, Xiao-xiao,Jing, Li-zhen,Liu, Guang-lei. 2008

[10]Nutritive Value of Sorghum Dried Distillers Grains with Solubles and its Effect on Performance in Geese. Wang, Chao,Huang, Yong,Zhao, Xianzhi,Gao, Guangliang,Wang, Yangming,Peng, Xiangwei,Wang, Qigui,Xie, Ming. 2018

[11]Effects of fasting and excreta collection period on the apparent and true metabolizable energy of corn and dehydrated alfalfa meal in ganders. Wang, Z. Y.,Shi, S. R.,Yang, H. M.,Sheng, D. F.,Lu, J.,Li, W. Z.,Shi, S. R.. 2010

[12]Effect of rice husk diluted dietary switching on body weight, carcass yield and digestive tract of adult ganders. Lu, J.,Wang, Z. Y.,Yang, H. M.,Shi, S. R.,Zou, J. M.. 2011

[13]Metabolizable energy and fiber digestibility of uncommon feedstuffs for geese. Zhang, S. J.,Zhu, C. H.,Guo, J.,Tang, Q. P.,Li, H. F.,Zou, J. M.. 2013

[14]LPAIV H9N2 Drives the Differential Expression of Goose Interferons and Proinflammatory Cytokines in Both In Vitro and In Vivo Studies. Zhou, Hao,Chen, Shun,Yan, Bing,Wang, Mingshu,Jia, Renyong,Liu, Mafeng,Yang, Qiao,Wu, Ying,Sun, Kunfeng,Cheng, Anchun,Chen, Shun,Wang, Mingshu,Jia, Renyong,Zhu, Dekang,Yang, Qiao,Wu, Ying,Sun, Kunfeng,Chen, Xiaoyue,Cheng, Anchun,Chen, Shun,Wang, Mingshu,Jia, Renyong,Zhu, Dekang,Liu, Fei,Yang, Qiao,Wu, Ying,Sun, Kunfeng,Chen, Xiaoyue,Jing, Bo,Cheng, Anchun,Chen, Hongjun. 2016

[15]Genetic, antigenic, and pathogenic characteristics of Newcastle disease viruses isolated from geese in China. Xu, Qianqian,Sun, Junfeng,Gao, Mengying,Zhao, Shasha,Liu, Huairan,Zhang, TingTing,Han, Zongxi,Kong, Xiangang,Liu, Shengwang.

[16]Nutritive value of dry citrus pulp and its effect on performance in geese from 35 to 70 days of age. Wang, C.,Gao, G. L.,Huang, J. X.,Zhang, K. S.,Zhong, H.,Wang, H. W.,Su, J.,Wang, Q. G.,Xie, M..

[17]Unique sequence characteristics of genes in the leftmost region of unique long region in duck enteritis virus. Liu, Xiaoli,Liu, Shengwang,Li, Huixin,Han, Zongxi,Shao, Yuhao,Kong, Xiangang.

[18]Effect of feed consumption levels on growth performance and carcass composition during the force-feeding period in foie gras production of male Mule ducks. Wen, Z. G.,Jiang, Y.,Tang, J.,Xie, M.,Hou, S. S.,Wen, Z. G.,Yang, P. L.,Jiang, Y.,Tang, J..

[19]Effects of alfalfa meal on the intestinal microbial diversity and immunity of growing ducks. Jiang, J. F.,Song, X. M.,Wu, J. L.,Jiang, Y. Q..

[20]Effects of dietary protein on threonine requirements of Pekin ducks from hatch to 21 days of age. Jiang, Y.,Uzma, M.,Tang, T.,Hou, S. S.,Huang, W.,Xie, M.,Jiang, Y.,Tang, T.,Wen, Z. G..

作者其他论文 更多>>

微信小程序