Promotion of Sophora subprosrate polysaccharide on nitric oxide and interleukin-2 production in murine T lymphocytes: implicated Ca2+ and protein kinase C

文献类型： 外文期刊

第一作者： Hu, TJ

作者： Hu, TJ;Zheng, RL

作者机构：

关键词： Sophora subprosrate polysaccharide;T lymphocytes;Ca2+;protein kinase C

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

ISSN： 1567-5769

年卷期： 2004 年 4 卷 1 期

页码：

收录情况： SCI

摘要： SSP1, a polysaccharide isolated from Sophora subprosrate, increased the productions of nitric oxide (NO) and interleukin-2 (IL-2) in murine splenic T lymphocytes. SSP1-treated T lymphocytes showed an enhanced activity of protein kinase C (PKC) from the cellular membrane fraction as well as an increase in concentration of cytoplasmic free Ca2+. The results showed that SSP1 activated T cells to release NO and secrete IL-2 by modulating activity of PKC and level of intracellular free calcium. Nifedipine, a Ca2+ blocker, inhibited the activation of T cells by SSP1, indicating a role of Ca2+ in the activation of T cells. SSP1-treated T cells showed an enhanced translocation of PKC, indicating that SSP1 activated T cells via the activation of PKC. (C) 2004 Elsevier B.V. All rights reserved.

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