ORF1a of highly pathogenic PRRS attenuated vaccine virus plays a key role in neutralizing antibody induction in piglets and virus neutralization in vitro
文献类型: 外文期刊
第一作者: Leng, Chaoliang
作者: Leng, Chaoliang;Zhang, Wuchao;Zhang, Hongliang;Li, Zhen;Liu, Chunxiao;An, Tongqing;Peng, Jinmei;Wang, Qian;Cai, Xuehui;Tian, Zhijun;Tong, Guangzhi;Leng, Chaoliang;Kan, Yunchao;Yao, Lunguang;Zhai, Hongyue;Li, Mingliang;Leng, Yumin;Tong, Guangzhi
作者机构:
关键词: PRRSV;Chimeric virus;Neutralizing antibody;Neutralization region
期刊名称:VIROLOGY JOURNAL ( 影响因子:4.099; 五年影响因子:3.719 )
ISSN: 1743-422X
年卷期: 2017 年 14 卷
页码:
收录情况: SCI
摘要: Background: Currently, porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viral pathogens in swine in most countries, especially China. Two PRRSV attenuated live vaccine strains (HuN4-F112 and CH-1R) are currently widely used in China. Our previous study showed that HuN4-F112, but not CH-1R, induced high anti-nucleocapsid (N) antibody and neutralizing antibody (NA) titers. Additionally, sera from HuN4-F112 inoculated pigs induced low cross neutralization of CH-1R. Methods: In the present study, 6 chimeric viruses through exchanging 5' untranslated region (UTR) + open reading frame (ORF) 1a, ORF1b, and ORF2-7 + 3'UTR between HuN4-F112 and CH-1R were constructed and rescued based on the infectious clones of rHuN4-F112 and rCH-1R. The characteristics of these viruses were investigated in vitro and vivo. Results: All the three fragments, 5' UTR + ORF1a, ORF1b, and ORF2-7 + 3'UTR, could affect the replication efficiencies of rHuN4-F112 and rCH-1R in vitro. Additionally, both 5' UTR + ORF1a and ORF2-7 + 3'UTR affected the anti-N antibody and NA responses targeting rHuN4-F112 and rCH-1R in piglets. Conclusions: The 5' UTR + ORF1a region of HuN4-F112 played a key role in inducing NAs in piglets. Furthermore, we confirmed for the first time that ORF1a contains a neutralization region. This study provides important information that can be used for further study of the generation of anti-PRRSV NAs.
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