Dietary Propolis Ameliorates Dextran Sulfate Sodium-Induced Colitis and Modulates the Gut Microbiota in Rats Fed aWestern Diet

文献类型： 外文期刊

第一作者： Wang, Kai

作者： Wang, Kai;Tian, Wenli;Wu, Liming;Wang, Kai;You, Mengmeng;Hu, Fuliang;Wang, Kai;Topping, David L.;Conlon, Michael A.;Jin, Xiaolu;Le Leu, Richard K.

作者机构：

关键词： propolis;rats;colitis;gut microbiota

期刊名称：NUTRIENTS （ 影响因子：5.717； 五年影响因子：6.349 ）

ISSN： 2072-6643

年卷期： 2017 年 9 卷 8 期

页码：

收录情况： SCI

摘要： Propolis is an important hive product and considered beneficial to health. However, evidence of its potential for improving gut health is still lacking. Here we use rats to examine whether dietary supplementation with propolis could be used as a therapy for ulcerative colitis. Rats were fed with a Western style diet alone (controls) or supplemented with different amounts of Chinese propolis (0.1%, 0.2%, and 0.3%) to examine effects on acute colitis induced by 3% dextran sulphate sodium (DSS) in drinking water. Propolis at 0.3%, but not lower levels, significantly improved colitis symptoms compared with the control group, with a less pronounced disease activity index (DAI) (p < 0.001), a significant increase in colon length/weight ratio (p < 0.05) and an improved distal colon tissue structure as assessed by histology. Although short chain fatty acid levels in digesta were not altered by propolis supplementation, 16S rRNA phylogenetic sequencing revealed a significant increase in gut microbial diversity after 21 days of 0.3% propolis supplementation compared with controls including a significant increase in bacteria belonging to the Proteobacteria and Acidobacteria phyla. This is the first study to demonstrate that propolis can attenuate DSS-induced colitis and provides new insight into diet-microbiota interactions during inflammatory bowel disease.

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