Kobuvirus VP3 protein restricts the IFN-beta-triggered signaling pathway by inhibiting STAT2-IRF9 and STAT2-STAT2 complex formation

文献类型: 外文期刊

第一作者: Peng, Qianqian

作者: Peng, Qianqian;Lan, Xi;Wang, Chen;Wang, Junyong;Zhu, Qiyun;Ren, Yujie;Yue, Ningning;Zhong, Bo;Zhong, Bo

作者机构:

关键词: Porcine kobuvirus;VP3;IFN-beta;STAT2;IRF9;Signaling pathway

期刊名称:VIROLOGY ( 影响因子:3.616; 五年影响因子:3.967 )

ISSN: 0042-6822

年卷期: 2017 年 507 卷

页码:

收录情况: SCI

摘要: Emerged porcine kobuvirus (PKV) has adversely affected the global swine industry since 2008, but the etiological biology of PKV is unclear. Screening PKV-encoded structural and non-structural proteins with a type I IFN-responsive luciferase reporter showed that PKV VP3 protein inhibited the IFN-beta-triggered signaling pathway, resulting in the decrease of VSV-GFP replication. QPCR data showed that IFN-beta downstream cytokine genes were suppressed without cell-type specificity as well. The results from biochemical experiments indicated that PKV VP3 associated with STAT2 and IRF9, and interfered with the formation of the STAT2-IRF9 and STAT2-STAT2 complex, impairing nuclear translocation of STAT2 and IRF9. Taken together, these data reveal a new mechanism for immune evasion of PKV.

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