The Taxus genome provides insights into paclitaxel biosynthesis

文献类型： 外文期刊

第一作者： Xiong, Xingyao

作者： Xiong, Xingyao;Li, Yanlin;Xiong, Xingyao;Gou, Junbo;Liao, Qinggang;Zhou, Qian;Bi, Guiqi;Li, Chong;Du, Ran;Wang, Xiaotong;Sun, Tianshu;Liang, Haifei;Lu, Pengjun;Wu, Yaoyao;Ro, Dae-Kyun;Huang, Sanwen;Yan, Jianbin;Li, Yanlin;Zhou, Qian;Guo, Lvjun;Zhang, Zhonghua;Ro, Dae-Kyun;Shang, Yi

作者机构：

期刊名称：NATURE PLANTS （ 影响因子：15.793； 五年影响因子：17.349 ）

ISSN： 2055-026X

年卷期： 2021 年 7 卷 8 期

页码：

收录情况： SCI

摘要： The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome of Taxus chinensis var. mairei with a total length of 10.23 gigabases. Taxus shared an ancestral whole-genome duplication with the coniferophyte lineage and underwent distinct transposon evolution. We discovered a unique physical and functional grouping of CYP725As (cytochrome P450) in the Taxus genome for paclitaxel biosynthesis. We also identified a gene cluster for taxadiene biosynthesis, which was formed mainly by gene duplications. This study will facilitate the elucidation of paclitaxel biosynthesis and unleash the biotechnological potential of Taxus. A high-quality Taxus genome provides insight into the genome evolution of the Taxus genus and the biosynthesis of paclitaxel.

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