chTLR4 pathway activation by Astragalus polysaccharide in bursa of Fabricius

文献类型： 外文期刊

第一作者： Zhang Ruili

作者： Zhang Ruili;Yu Qun;Shi Guangliang;Liu Rui;Zhang Weiqian;Zhao Xia;Li Guangxing;Ge Ming;Yu Qun

作者机构：

关键词： Astragalus polysaccharide;Bursa of Fabricius;Innate immunity;Toll-like receptor 4

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）

ISSN： 1746-6148

年卷期： 2017 年 13 卷

页码：

收录情况： SCI

摘要： Background: The Toll-like receptor 4 (TLR4) pathway involves in the pathogen recognition and defense against infection in mammals. Considering that avian and mammalian TLR are differentially mediated, the action of a natural product on avian TLR4 pathway was unclear. High, medium and low doses of Astragalus polysaccharide (APS), were treated the chicken at 7-days-old age by gavage. The sIgA level in the intestinal fluid, the expression of chTLR4 mRNA/protein in bursa of Fabricius as well as the expression of downstream molecules of chTLR4 (chMyD88, chTRIF, chNF-kappa B, chIRF3, chIFN-beta and chTNF-alpha) were measured on alternate days. Results: The content of sIgA and the chTLR4 mRNA expression/protein level were increased in non-dose-dependent manner after APS supplement. Also, the expressions of a subset of MyD88-independent pathway genes were more than MyD88-independent, in particular with low doses of APS supplement for 7 days. Conclusions: These suggest that administration of APS activates chTLR4 pathway in bursa of Fabricius in MyD88-independent pathway. Meanwhile, low dose of APS shows better performance regarding the activation of chTLR4 and regulation of MyD88-independent pathway.

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