Dissecting the role of AMP-activated protein kinase in human diseases
文献类型: 外文期刊
第一作者: Li, Jin
作者: Li, Jin;Wang, Fengzhong;Zhong, Liping;Zhu, Haibo;Zhu, Haibo;Zhu, Haibo;Zhu, Haibo
作者机构:
关键词: AMPK;Cancer;Type 2 diabetes;Atherosclerosis;Myocardial isehelmia;Neurodegenerative disease
期刊名称:ACTA PHARMACEUTICA SINICA B ( 影响因子:11.413; 五年影响因子:10.745 )
ISSN: 2211-3835
年卷期: 2017 年 7 卷 3 期
页码:
收录情况: SCI
摘要: AMP-activated protein kinase (AMPK), known as a sensor and a master of cellular energy balance, integrates various regulatory signals including anabolic and catabolic metabolic processes. Accompanying the application of genetic methods and a plethora of AMPK agonists, rapid progress has identified AMPK as an attractive therapeutic target for several human diseases, such as cancer, type 2 diabetes, atherosclerosis, myocardial ischemia/reperfusion injury and neurodegenerative disease. The role of AMPK in metabolic and energetic modulation both at the intracellular and whole body levels has been reviewed elsewhere. In the present review, we summarize and update the paradoxical role of AMPK implicated in the diseases mentioned above and put forward the challenge encountered. Thus it will be expected to provide important clues for exploring rational methods of intervention in human diseases. (C) 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
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