Dissecting the role of AMP-activated protein kinase in human diseases
文献类型: 外文期刊
第一作者: Li, Jin
作者: Li, Jin;Wang, Fengzhong;Zhong, Liping;Zhu, Haibo;Zhu, Haibo;Zhu, Haibo;Zhu, Haibo
作者机构:
关键词: AMPK;Cancer;Type 2 diabetes;Atherosclerosis;Myocardial isehelmia;Neurodegenerative disease
期刊名称:ACTA PHARMACEUTICA SINICA B ( 影响因子:11.413; 五年影响因子:10.745 )
ISSN: 2211-3835
年卷期: 2017 年 7 卷 3 期
页码:
收录情况: SCI
摘要: AMP-activated protein kinase (AMPK), known as a sensor and a master of cellular energy balance, integrates various regulatory signals including anabolic and catabolic metabolic processes. Accompanying the application of genetic methods and a plethora of AMPK agonists, rapid progress has identified AMPK as an attractive therapeutic target for several human diseases, such as cancer, type 2 diabetes, atherosclerosis, myocardial ischemia/reperfusion injury and neurodegenerative disease. The role of AMPK in metabolic and energetic modulation both at the intracellular and whole body levels has been reviewed elsewhere. In the present review, we summarize and update the paradoxical role of AMPK implicated in the diseases mentioned above and put forward the challenge encountered. Thus it will be expected to provide important clues for exploring rational methods of intervention in human diseases. (C) 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
分类号:
- 相关文献
作者其他论文 更多>>
-
Analysis of oil-water interface behavior of soy protein isolate-/3-Lactoglobulin blend system and rheological properties in high internal phase emulsion
作者:Qiu, Runkang;Ma, Peihua;Chen, Zhaoshi;Luo, Huanxiang;Liu, Linggao;Fan, Bei;Tong, Litao;Wang, Lili;Liu, Liya;Wang, Fengzhong;Fan, Bei;Tong, Litao;Liu, Liya;Wang, Fengzhong;Fan, Bei;Liu, Liya;Wang, Fengzhong
关键词:Soy protein isolate (SPI); High internal phase emulsions; Interfacial rheology; Dynamic large oscillation rheology
-
Texture and structure of high-moisture extrudates produced from soybean protein isolates with different 7S/11S globulin ratios
作者:Fei, Chengxin;Li, Lin;Zhao, Ruojie;Wang, Xinrui;Fan, Bei;Liu, Liya;Wang, Fengzhong;Huang, Yatao;Wang, Fengzhong;Huang, Yatao
关键词:Soybean protein isolate; 7S/11S ratio; High-moisture extrusion; Texture
-
Development of whole highland barley ready-to-eat 3D printed dysphagia diet: Effect of heat treatment
作者:Kou, Delin;Zhao, Peiyao;Qiu, Runkang;Fan, Bei;Tong, Litao;Wang, Lili;Liu, Liya;Wang, Fengzhong;Kou, Delin;Li, Yifei;Fan, Bei;Liu, Liya;Wang, Fengzhong;Fan, Bei;Liu, Liya;Wang, Fengzhong
关键词:Whole grain food; Highland barley; 3D printing; Dysphagia
-
Efficient conversion of insoluble dietary fiber to soluble dietary fiber by Bacillus subtilis BSNK-5 fermentation of okara and improvement of their structural and functional properties
作者:Meng, Weimin;Hu, Miao;Zhang, Pengfei;Wang, Jiao;Yuan, Zifan;Wang, Fengzhong;Li, Shuying;Wang, Fengzhong;Wang, Fengzhong
关键词:Okara; Soluble dietary fiber; Insoluble dietary fiber; Bacillus subtilis; Processing characteristics; Functional characteristics
-
Development of soy protein emulsion gels-based 3D printed dysphagia foods: Effects of the egg white protein supplementation
作者:Zhao, Peiyao;Kou, Delin;Qiu, Runkang;Tong, Litao;Wang, Lili;Fan, Bei;Wang, Fengzhong;Liu, Liya;Li, Shugang;Awais, Muhammad
关键词:3D printing; Soy protein isolate; Egg white protein; Dysphagia food
-
Natural variation of CTB5 confers cold adaptation in plateau japonica rice
作者:Guo, Haifeng;Gao, Shilei;Li, Jin;Gu, Yunsong;Lou, Qijin;Su, Runbin;Ye, Wei;Zou, Andong;Wang, Yulong;Sun, Xingming;Zhang, Zhanying;Zhang, Hongliang;Li, Zichao;Li, Jinjie;Guo, Haifeng;Peng, Youliang;Li, Huahui;Yuan, Pingrong;Yang, Jiazhen;Zeng, Yawen
关键词:
-
The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models
作者:Liu, Yalan;Tan, Jianxin;Liu, Yalan;Wang, Fengzhong;Li, Lin;Fan, Bei;Li, Minmin;Kong, Zhiqiang
关键词:Pesticides; Endocrine-disrupting effect; Estrogen receptor; Cell models; Toxic mechanism