Research advances on plectasin and its derivatives as new potential antimicrobial candidates
文献类型: 外文期刊
第一作者: Li, Zhanzhan
作者: Li, Zhanzhan;Wang, Xiumin;Wang, Xiao;Teng, Da;Mao, Ruoyu;Hao, Ya;Wang, Jianhua;Li, Zhanzhan;Wang, Xiumin;Wang, Xiao;Teng, Da;Mao, Ruoyu;Hao, Ya;Wang, Jianhua
作者机构:
关键词: Plectasin;Derivative;Antimicrobial peptide;Modification;Expression;Mechanism
期刊名称:PROCESS BIOCHEMISTRY ( 影响因子:3.757; 五年影响因子:3.665 )
ISSN: 1359-5113
年卷期: 2017 年 56 卷
页码:
收录情况: SCI
摘要: Plectasin is a cationic antimicrobial peptide (AMP) that is 40 residues long and belongs to the cysteine-stabilized alpha-helix and beta-sheet superfamily. This peptide, which was first isolated from the saprophytic fungus Pseudoplectania nigrella, exhibits strong bactericidal activity toward several gram positive pathogens, including Staphylococcus aureus and Streptococcus pneumoniae. In this review, we discuss the latest advances made to improve plectasin antimicrobial activity and reduce its cytotoxicity, namely a variety of methods for the design and construction of plectasin derivatives, hybrids, and available expression systems. In addition, we focused on the investigations regarding the biological activity, therapeutic properties, and mechanisms of action of this promising antibiotic. (C) 2017 Elsevier Ltd. All rights reserved.
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