Brain Concentration of Ginsenosides and Pharmacokinetics after Oral Administrationof Mountain-cultivated Ginseng

文献类型： 外文期刊

第一作者： Li, Meijia

作者： Li, Meijia;Guan, Yiming;Liu, Ning;Shao, Cai;Liu, Zhengbo;Chen, Jianbo;Wang, Qiuxia;Pan, Xiaoxi;Sun, Hai;Zhang, Yayu

作者机构：

关键词： Mountain-cultivated ginseng;Cultivated ginseng;Bioavailability;Ginsenoside;Ultra-performance liquid chromatography-tandem mass spectrometry;Pharmacokinetics

期刊名称：JOURNAL OF THE CHINESE CHEMICAL SOCIETY （ 影响因子：1.967； 五年影响因子：1.639 ）

ISSN： 0009-4536

年卷期： 2017 年 64 卷 4 期

页码：

收录情况： SCI

摘要： Mountain-cultivated ginseng (MCG) can be considered a mimic of wild ginseng, whose seeds are sowed artificially, cultivated in the natural environment, and returned to the wild state before being used clinically. Cultivated ginseng (CG) and MCG are mainly used as the commercial material for clinical applications. However, MCG is much more expensive but effective than CG. The aim of this study is to explore the differences in the pharmacokinetics and brain concentration of Rg1, Re, Rb1, and Rd after oral administration of MCG, CG, and pure ginsenosides. An ultra-performance liquid chromatography-tandem mass spectrometry method was developed and validated to determine the concentration of the four ginsenosides in rat plasma and brain tissue. Compared with the pure group, the area under the curve (AUC) of all the four ginsenosides for CG and MCG increased. The mean brain concentrations of the four ginsenosides were found to be 10- to 15-fold lower than the corresponding contents in the plasma, and the poor permeability of ginsenosides into blood-brain barrier was indicated by the low concentrations of the four ginsenosides.

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