The Interactions between ZnO Nanoparticles (NPs) and alpha-Linolenic Acid (LNA) Complexed to BSA Did Not Influence the Toxicity of ZnO NPs on HepG2 Cells

文献类型: 外文期刊

第一作者: Zhou, Yiwei

作者: Zhou, Yiwei;Fang, Xin;Xiao, Aiping;Liu, Liangliang;Cao, Yi;Zhou, Yiwei;Fang, Xin;Gong, Yu;Xie, Yixi;Cao, Yi

作者机构:

关键词: HepG2 cells;alpha-linolenic acid (LNA);ZnO nanoparticles;interaction

期刊名称:NANOMATERIALS ( 影响因子:5.076; 五年影响因子:5.346 )

ISSN: 2079-4991

年卷期: 2017 年 7 卷 4 期

页码:

收录情况: SCI

摘要: Background: Nanoparticles (NPs) entering the biological environment could interact with biomolecules, but little is known about the interaction between unsaturated fatty acids (UFA) and NPs. Methods: This study used alpha-linolenic acid (LNA) complexed to bovine serum albumin (BSA) for UFA and HepG2 cells for hepatocytes. The interactions between BSA or LNA and ZnO NPs were studied. Results: The presence of BSA or LNA affected the hydrodynamic size, zeta potential, UV-Vis, fluorescence, and synchronous fluorescence spectra of ZnO NPs, which indicated an interaction between BSA or LNA and NPs. Exposure to ZnO NPs with the presence of BSA significantly induced the damage to mitochondria and lysosomes in HepG2 cells, associated with an increase of intracellular Zn ions, but not intracellular superoxide. Paradoxically, the release of inflammatory cytokine interleukin-6 (IL-6) was decreased, which indicated the anti-inflammatory effects of ZnO NPs when BSA was present. The presence of LNA did not significantly affect all of these endpoints in HepG2 cells exposed to ZnO NPs and BSA. Conclusions: the results from the present study indicated that BSA-complexed LNA might modestly interact with ZnO NPs, but did not significantly affect ZnO NPs and BSA-induced biological effects in HepG2 cells.

分类号:

  • 相关文献

[1]The presence of oleate stabilized ZnO nanoparticles (NPs) and reduced the toxicity of aged NPs to Caco-2 and HepG2 cells. Fang, Xin,Jiang, Leying,Gong, Yu,Li, Juan,Cao, Yi,Liu, Liangliang,Cao, Yi.

[2]Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway. Wang, Congcong,Tang, Shusheng,Zhao, Dongxu,Zhang, Chaoming,Zhang, Shen,Deng, Sijun,Zhou, Yan,Xiao, Xilong,Wang, Congcong,Li, Tao.

[3]Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles. Guan, Rongfa,Kang, Tianshu,Liu, Mingqi,Lu, Fei,Zhang, Zhiguo,Shen, Haitao. 2012

[4]Zinc Oxide Nanoparticles Influence Microflora in Ileal Digesta and Correlate Well with Blood Metabolites. Feng, Yanni,Min, Lingjiang,Zhang, Weidong,Chu, Meiqiang,Li, Lan,Shen, Wei,Zhao, Yong,Zhang, Hongfu,Liu, Jing,Hou, Zhumei,Zhao, Yong. 2017

[5]Molecular evidence of offspring liver dysfunction after maternal exposure to zinc oxide nanoparticles. Hao, Yanan,Feng, Yanni,Yu, Shuai,Zhang, Weidong,Li, Lan,Min, Lingjiang,Shen, Wei,Zhao, Yong,Liu, Jing,Zhang, Hongfu,Zhao, Yong.

[6]Preparation of Carriers Based on ZnO Nanoparticles Decorated on Graphene Oxide (GO) Nanosheets for Efficient Immobilization of Lipase from Candida rugosa. Zhang, Shan,Shi, Jie,Deng, Qianchun,Zheng, Mingming,Wan, Chuyun,Zheng, Chang,Li, Ya,Huang, Fenghong.

[7]Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the gamma-H2AX and NF-kappa B signaling pathways. Liu, Jing,Zhao, Yong,Ge, Wei,Zhang, Pengfei,Liu, Xinqi,Zhang, Weidong,Hao, Yanan,Yu, Shuai,Li, Lan,Chu, Meiqiang,Min, Lingjiang,Shen, Wei,Liu, Jing,Zhao, Yong,Zhang, Hongfu. 2017

[8]Simultaneous determination of anabolic steroids and beta-agonists in milk by QuEChERS and ultra high performance liquid chromatography tandem mass spectrometry. Liu, Hongcheng,Lin, Tao,Li, Ning,Wang, Luxiang,Li, Qiwan,Liu, Hongcheng,Lin, Tao,Li, Ning,Wang, Luxiang,Li, Qiwan,Liu, Hongcheng,Lin, Tao,Li, Ning,Wang, Luxiang,Li, Qiwan,Cheng, Xianglei,Li, Ning.

[9]Effect of Cr(VI) on Fe(III) reduction in three paddy soils from the Hani terrace field at high altitude. Li, Xiao-min,Liu, Tong-xu,Li, Fang-bai,Zhang, Nai-ming,Ren, Guo,Li, Xiao-min,Li, Yong-tao. 2012

[10]Overexpression of OsCIPK30 Enhances Plant Tolerance to Rice stripe virus. Liu, Zhiyang,Li, Xuejuan,Sun, Feng,Zhou, Tong,Zhou, Yijun,Liu, Zhiyang,Li, Xuejuan,Sun, Feng,Zhou, Tong,Zhou, Yijun. 2017

[11]Which Factors Determine Metal Accumulation in Agricultural Soils in the Severely Human-Coupled Ecosystem?. Xu, Li,Cao, Shanshan,Wang, Jihua,Lu, Anxiang,Xu, Li,Cao, Shanshan,Wang, Jihua,Lu, Anxiang. 2016

[12]Mouse hepatitis virus nucleocapsid protein interacts receptor for activated C kinase1, and regulates AKT signal pathway. Zhang, Pengju,Wu, Xinghong,Wang, Jun,Long, Miao. 2017

[13]Functional Genomic Analysis of Aspergillus flavus Interacting with Resistant and Susceptible Peanut. Wang, Houmiao,Lei, Yong,Yan, Liying,Wan, Liyun,Ren, Xiaoping,Chen, Silong,Jiang, Huifang,Liao, Boshou,Wang, Houmiao,Lei, Yong,Yan, Liying,Wan, Liyun,Ren, Xiaoping,Chen, Silong,Jiang, Huifang,Liao, Boshou,Dai, Xiaofeng,Guo, Wei. 2016

[14]Nonstructural protein P7-2 encoded by Rice black-streaked dwarf virus interacts with SKP1, a core subunit of SCF ubiquitin ligase. Wang, Qian,Wang, Qian,Tao, Tao,Han, Yanhong,Chen, Xiangru,Fan, Zaifeng,Li, Dawei,Yu, Jialin,Han, Chenggui,Wang, Qian,Tao, Tao,Han, Yanhong,Chen, Xiangru,Fan, Zaifeng,Li, Dawei,Yu, Jialin,Han, Chenggui. 2013

[15]F(0)ATP synthase b-chain of Litopenaeus vannamei involved in White Spot Syndrome Virus infection. Li, Qian,Liu, Qing-hui,Huang, Jie,Li, Qian. 2013

[16]Study on Interaction between Coomassie Brilliant Blue G-250 and Bovine Serum Albumin by Fluorescence Spectroscopy and Molecular Modeling. Wang Yong-gang,Yang Guang-rui,Leng Fei-fan,Ma Jian-zhong,Ma Xue-qing,Wang Xiao-li. 2017

[17]Genomic prediction with epistasis models: on the marker-coding-dependent performance of the extended GBLUP and properties of the categorical epistasis model (CE). Martini, Johannes W. R.,Gao, Ning,Cardoso, Diercles F.,Erbe, Malena,Simianer, Henner,Gao, Ning,Cardoso, Diercles F.,Cardoso, Diercles F.,Erbe, Malena,Cantet, Rodolfo J. C.. 2017

[18]Interaction of heat shock protein 90 B1 (Hsp90B1) with liposome reveals its potential role in protection the integrity of lipid membranes. Li, Pengpeng,Zhang, Muhan,Zou, Ye,Sun, Zhilan,Sun, Chong,Geng, Zhiming,Xu, Weimin,Wang, Daoying. 2018

[19]Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro. Li, Wenliang,Mao, Li,Yang, Leilei,Hao, Fei,Zhang, Wenwen,Jiang, Jieyuan,Cao, Yongguo,Zhou, Bin,Han, Linxiao,Lin, Tao. 2017

[20]Metabolomics Investigation of an Association of Induced Features and Corresponding Fungus during the Co-culture of Trametes versicolor and Ganoderma applanatum. Xu, Xiao-Yan,Shen, Xiao-Ting,Yuan, Xiao-Jie,Zhu, Li-Ping,Yang, Song,Zhou, Yuan-Ming,Fan, Huan,Du, Feng-Yu,Sadilek, Martin,Yang, Jie,Qiao, Bin,Yang, Song. 2018

作者其他论文 更多>>