The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

文献类型： 外文期刊

第一作者： Chang, Kang

作者： Chang, Kang;Chen, Jian-Qin;Li, Peng-Fei;Zhu, Wei-Ping;Xu, Yu-Fang;Qian, Xu-Hong;Sun, Mei-Jian;Zhao, Zhen-Jiang;Li, Hong-Lin;Shi, Yan-Xia;Li, Bao-Ju

作者机构：

关键词： Plant activator;Systemic acquired resistance;Salicylic acid;Benzotriazole;Virtual screening

期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：6.779； 五年影响因子：4.558 ）

ISSN： 1001-8417

年卷期： 2017 年 28 卷 4 期

页码：

收录情况： SCI

摘要： Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1'-position and 5'-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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