Foot-and-mouth disease virus-like particles as integrin-based drug delivery system achieve targeting anti-tumor efficacy

文献类型： 外文期刊

第一作者： Yan, Dan

作者： Yan, Dan;Teng, Zhidong;Sun, Shiqi;Dong, Hu;Gao, Yuan;Wei, Yanquan;Liu, Xiangtao;Yin, Hong;Guo, Huichen;Yan, Dan;Teng, Zhidong;Sun, Shiqi;Dong, Hu;Gao, Yuan;Wei, Yanquan;Liu, Xiangtao;Yin, Hong;Guo, Huichen;Jiang, Shan;Qin, Wenwu

作者机构：

关键词： FMDV VLPs;Integrin receptor;Drug delivery;Dox;Tumor therapy

期刊名称：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE （ 影响因子：6.458； 五年影响因子：7.072 ）

ISSN： 1549-9634

年卷期： 2017 年 13 卷 3 期

页码：

收录情况： SCI

摘要： The surface of foot-and-mouth disease virus (FMDV)-like particles (VLPs) contains a conserved arginine-glycine-aspartic acid (RGD) motif. Natural FMDV specifically attaches to overexpressed integrin receptors in several cancer cells. The FMDV VLPs produced in Escherichia coli were used for the first time as a delivery system of anti-tumor drug doxorubicin (DOX). The DOX-loaded VLPs exhibited a distinct release profile in different physiological conditions. The effects of FMDV-VLPs-DOX on cellular internalization and viability were evaluated in vitro by cell imaging, MTT assay and apoptosis, respectively. The anti-tumor efficacy in vivo was also determined in a nude mouse xenograft model based on tumor volume/weight and histological changes. The FMDV-VLPs-DOX complex significantly inhibited the proliferation of tumor and improved the pathological damage of DOX to non-targeting tissues. All results supported the potential of FMDV VLPs as a platform for specific targeted delivery of drugs or chemical reagents. (C) 2016 Elsevier Inc. All rights reserved.

分类号：

  • 相关文献

[1]Selective synthesis of Fe3O4AuxAgy nanomaterials and their potential applications in catalysis and nanomedicine. Fodjo, Essy Kouadio,Serge, Brou Yapi,Trokourey, Albert,Gabriel, Koffi Mouroufie,Li, Dan,Kong, Cong. 2017

[2]Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon. Li, Puwang,Yang, Ziming,Peng, Zheng,Li, Sidong,Kong, Lingxue,Wang, Qinghuang,Wang, Yichao,Kong, Lingxue,Wang, Qinghuang. 2015

[3]Cutting Edge Protein and Carbohydrate-Based Materials for Anticancer Drug Delivery. Ahmad, Rasheed,Deng, Yan,Hussain, Mubashir,He, Nongyue,Ahmad, Rasheed,Sun, Yueming,Shah, Muhammad Ali Abdullah,Singh, Ravina,Elingarami, Sauli,Deng, Yan,He, Nongyue. 2018

[4]The application of virus-like particles as vaccines and biological vehicles. Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi,Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi.

[5]Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer. Wang, Yichao,Wang, Yichao,Li, Puwang,Thao Truong-Dinh Tran,Zhang, Juan,Kong, Lingxue,Li, Puwang,Thao Truong-Dinh Tran. 2016

[6]Nanogels fabricated by lysozyme and sodium carboxymethyl cellulose for 5-fluorouracil controlled release. Zhu, Kunkun,Ye, Ting,Liu, Jinjin,Xu, Shasha,Lei, Jieqiong,Deng, Hongbing,Li, Bin,Zhu, Kunkun,Ye, Ting,Liu, Jinjin,Xu, Shasha,Lei, Jieqiong,Deng, Hongbing,Li, Bin,Zhu, Kunkun,Peng, Zheng.

[7]Nanostructured calcium phosphate carriers for deliver of poor water-soluble drug silybin. Chen, Lei,Zhu, Hualing,Yang, Song,Zhou, Beibei,You, Fenghui,Yan, Xiaoming.

作者其他论文 更多>>

微信小程序