Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential

文献类型: 外文期刊

第一作者: Miao Xiang-yang

作者: Miao Xiang-yang

作者机构:

关键词: miRNA;gene expression;gene regulation;gene transcription;exosomes;non-coding RNA

期刊名称:JOURNAL OF INTEGRATIVE AGRICULTURE ( 影响因子:2.848; 五年影响因子:2.979 )

ISSN: 2095-3119

年卷期: 2017 年 16 卷 4 期

页码:

收录情况: SCI

摘要: MicroRNAs (miRNAs) are small endogenous non-protein coding RNAs that range in size from 19-25 nucleotides. Thousands of miRNA genes have been identified in a variety of organisms, suggesting genetic exchange and distribution among species. miRNAs negatively regulate gene expression by binding to the 3'-untranslated regions (3'-UTRs) of their target genes and play an important role in growth, development and the occurrence of diseases. In this review, we summarize the recent advances in the understanding of the role of miRNAs in exosomes and their therapeutic potential, as well as provide an overview of the basic characteristics of miRNAs.

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