Up-regulation of miR-182-5p predicts poor prognosis in patients with lung cancer and associates with tumor cell growth and migration

文献类型： 外文期刊

第一作者： Shi, Yuanyuan

作者： Shi, Yuanyuan;Liu, Hao;Du, Xiang;Liu, Xuedong;Liu, Jing

作者机构：

关键词： MiR-182-5p;lung cancer;prognosis;proliferation;migration

期刊名称：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY （ 影响因子：0.252； 五年影响因子：1.188 ）

ISSN： 1936-2625

年卷期： 2017 年 10 卷 3 期

页码：

收录情况： SCI

摘要： microRNA-182-5p (miR-182-5p) has been shown to be associated with tumorigenesis in various types of human cancers. However, the clinical significance and roles of miR-182-5p in lung cancer have not been illustrated. The aim of this study was to assess the effects of miR-182-5p in lung cancer and its potential relevance to clinicopathological characteristics and survival. Here, we found that miR-182-5p was markedly upregulatedin lung cancer tissues and cell lines compared with adjacent non-tumor tissues and normal bronchial epithelial cell. The high expression of miR-182-5p was found to be significantly associated with lymph nodes metastasis. The lung cancer patients with high miR-182-5 p expression had a notably shorter overall survival than those with low miR-182-5 p expression. Furthermore, multivariate cox proportional hazards model showed that expression of miR-182-5 p was independent prognostic factors for overall survival of patients with lung cancer. In addition, by 3-(4,5-dimethylthi-azol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) and wound scratch assays, we found that knock-down of miR-182-5p resulted in retarded cell proliferation and migration in lung cancer. In summary, our findings indicate that miR-182-5p silencing suppresses the growth and migration of lung cancer and its up-regulation expression is associated with unfavorable prognosis, suggesting that miR-182-5p may be a promising biomarker for further risk stratification in the treatment of this cancer.

分类号：

  • 相关文献

[1]FIP-sch2, a new fungal immunomodulatory protein from Stachybotrys chlorohalonata, suppresses proliferation and migration in lung cancer cells. Li, Shuying,Jiang, Zhonghao,Xu, Wenyi,Xie, Yingying,Zhao, Leiming,Tang, Xuanming,Wang, Fengzhong,Xin, Fengjiao.

[2]Characterization of a new fungal immunomodulatory protein, FIP-dsq2 from Dichomitus squalens. Li, Shuying,Jiang, Zhonghao,Sun, Lichao,Liu, Xin,Huang, Ying,Wang, Fengzhong,Xin, Fengjiao.

[3]Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/beta-Catenin Signaling. Zhang, Haihua,Wang, Shiyong,Zhang, Tietao,Yang, Fuhe,Li, Guangyu,Nan, Weixiao,Si, Huazhe. 2016

[4]Knockdown of HIF-1 alpha inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro: An involvement of Shh pathway. Zhang, Haihua,Song, Xingchao,Wang, Shiyong,Si, Huazhe,Li, Guangyu,Nan, Weixiao. 2017

[5]Integrated High Throughput Analysis Identifies GSK3 as a Crucial Determinant of p53-Mediated Apoptosis in Lung Cancer Cells. Zhang, Yu,Zhu, Chenyang,Lv, Jiawei,Liu, Zhonghua,Zhu, Chenyang,Sun, Bangyao,Liu, Shengwang,Li, Hai. 2017

[6]Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation. Peng, Min,Shi, Liqiao,Ke, Shaoyong. 2017

[7]Differential Expression of miR-125a-5p and let-7e Predicts the Progression and Prognosis of Non-Small Cell Lung Cancer. Le, Han-bo,Zhang, Yong-Kui,Zhu, Wang-Yu,Luo, Bin,He, Jian-ying,Chen, Dong-dong,Xu, Li-Yun,Huang, Yan-Yan,Liu, Xiao-Guang,An, Ji-yuan. 2014

[8]Oncolytic therapy of a recombinant Newcastle disease virus D90 strain for lung cancer. Chai, Zheng,Fu, Fang,Zhang, Xueyun,Li, Xi,Zhang, Peiyi,Liu, Ying,Hu, Lihua. 2014

[9]Wnt5a as a Predictor in Poor Clinical Outcome of Patients and a Mediator in Chemoresistance of Ovarian Cancer. Peng, Chunjie,Zhang, Xiaolei,Yu, Hongli,Zheng, Jianhua,Wu, Donglai. 2011

[10]Circulating miRNAs: Roles in cancer diagnosis, prognosis and therapy. Cheng, Guofeng.

[11]Chemical Characterization of a Procyanidin-Rich Extract from Sorghum Bran and Its Effect on Oxidative Stress and Tumor Inhibition in Vivo. Wu, Li,Huang, Zhaohui,Qin, Peiyou,Yao, Yang,Ren, Guixing,Huang, Zhaohui,Meng, Xianjun,Zou, Jianqiu,Zhu, Kai.

[12]Expression and prognostic value of ING3 in human primary hepatocellular carcinoma. Yang, Hai-Yan,Tian, Lan-Tian,Song, Rui-Peng,Song, Xuan,Yin, Da-Long,Liang, Ying-Jian,Jiang, Hong-Chi,Liu, Lian-Xin,Liu, Hao-Ling,Qu, Lian-Dong,Liu, Jia-Ren.

[13]Antimony release from contaminated mine soils and its migration in four typical soils using lysimeter experiments. Zhao, Long,Hou, Hong,Shangguan, Yu-xian,Qin, Yusheng,Zhang, Naiming.

[14]Molecular cloning, sequence analysis, and function of the intestinal epithelial stem cell marker Bmi1 in pig intestinal epithelial cells. Li, C. -M.,Yan, H. -C.,Fu, H. -L.,Xu, G. -F.,Wang, X. -Q.. 2014

[15]The Influence of Thidiazuron on Proliferation of Acer x freemanii In Vitro. Zhao, X. Q.,Yuan, Z. H.,Yin, Y. L.,Feng, L. J.,Yin, Y. L.,Xu, R.. 2012

[16]Effect of Auxins on In Vitro Propagation of Sour Jujube Infected by Witches' Broom Phytoplasma. Sun, Q.,Zhou, G.,Sun, H.,Giang, G.. 2009

[17]Effects of linoleic acid and eicosapentaenoic acid on cell proliferation and lipid-metabolism gene expression in primary duck hepatocytes. Liu, W. M.,Lu, L. Z.,Zhang, C.,Liu, Y. L.,Zhang, J.,Tao, Z. R.,Shen, J. D.,Li, G. Q.,Wang, D. Q.,Li, J. J.,Tian, Y.,Liu, W. M.,Shi, F. X.,Liu, Y. L.,Zhang, J.. 2011

[18]Relationship of flight and reproduction in beet armyworm, Spodoptera exigua (Lepidoptera: Noctuidae), a migrant lacking the oogenesis-flight syndrome. Jiang, Xing Fu,Luo, Li Zhi,Sappington, Thomas W.. 2010

[19]Spring migration and summer dispersal of Loxostege sticticalis (Lepidoptera : Pyralidae) and other insects observed with radar in Northern China. Wu, KM,Cheng, DF,Guo, YY. 2004

[20]Variation of pre-ovipositional period in the brown planthopper, Nilaparvata lugens, collected in tropical, subtropical and temperate Asia. Wada, T.,Ito, K.,Takahashi, A.,Tang, J.. 2007

作者其他论文 更多>>

微信小程序