Dibenzo-alpha-pyrones from the endophytic fungus Alternaria sp Samif01: isolation, structure elucidation, and their antibacterial and antioxidant activities

文献类型： 外文期刊

第一作者： Tian, Jin

作者： Tian, Jin;Fu, Linyun;Zhang, Zihao;Dong, Xuejiao;Xu, Dan;Mao, Ziling;Lai, Daowan;Zhou, Ligang;Tian, Jin;Liu, Yang

作者机构：

关键词： Endophytic fungus;dibenzo-alpha-pyrones;antibacterial;antioxidant;Alternaria sp.;Salvia miltiorrhiza

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

ISSN： 1478-6419

年卷期： 2017 年 31 卷 4 期

页码：

收录情况： SCI

摘要： The EtOAc extract of the liquid fermentation of Alternaria sp. Samif01, an endophytic fungus obtained from Salvia miltiorrhiza Bunge, showed antibacterial activity against several tested bacterial pathogens. Fractionation of this extract led to the isolation of seven dibenzo-alpha-pyrones (1-7), including one new compound, 2-acetoxy-2-epi-altenuene (1) and one new natural product, 3-epi-dihydroaltenuene A (2). The structures of the new metabolites were elucidated by comprehensive analysis of the spectroscopic data including (1D, 2D) NMR and HRESIMS, while the absolute configuration of 1 was determined by TDDFT-ECD computation. Altenuisol (5), 4-hydroxyalternariol-9-methyl ether (6), and alternariol (7) showed inhibitory activities against the tested bacteria with minimum inhibitory concentration values in the range of 86.7-364.7 mu M. A preliminary structure-antibacterial activity relationship was discussed. In addition, compounds 2, 5 and 6 displayed promising antioxidant effects using DPPH and hydroxyl radical assays. The cytotoxicity of the isolated compounds was evaluated as well. [GRAPHICS] . The endophytic fungus Alternaria sp. Samif01 isolated from Salvia miltiorrhiza Bunge produced seven bioactive dibenzo-alpha-pyrones, including one new compound (1), whose absolute configuration was determined by ECD calculation.

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