Synthesis, Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole

文献类型： 外文期刊

第一作者： Sun Guo-Xiang

作者： Sun Guo-Xiang;Zhai Zhi-Wen;Sun Zhao-Hui;Weng Jian-Quan;Tan Cheng-Xia;Liu Xing-Hai;Shi Yan-Xia;Li Bao-Ju

作者机构：

关键词： oxadiazole compound;synthesis;crystal structure;antifungal activity

期刊名称：CHINESE JOURNAL OF STRUCTURAL CHEMISTRY （ 影响因子：0.893； 五年影响因子：0.603 ）

ISSN： 0254-5861

年卷期： 2016 年 35 卷 12 期

页码：

收录情况： SCI

摘要： The title compound 2-((2-fluorobenzyl) thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole (C14H10FN3OS) was synthesized, and its structure was confirmed by H-1 NMR, MS, elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system, space group P2(1)/n with a = 11.541(16), b = 8.226(12), c = 13.683(19) angstrom, beta = 94.872(17)degrees, V = 1294(3)angstrom(3), Z = 4 and R = 0.0648 for 2198 observed reflections with I > 2s(I). The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.

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