Avian leukosis virus subgroup J induces VEGF expression via NF-kappa B/PI3K-dependent IL-6 production

文献类型: 外文期刊

第一作者: Gao, Yanni

作者: Gao, Yanni;Zhang, Yao;Guan, Xiaolu;Liu, Yongzhen;Qi, Xiaole;Wang, Yongqiang;Liu, Changjun;Zhang, Yanping;Gao, Honglei;Wang, Xiaomei;Gao, Yulong;Yao, Yongxiu;Nair, Venugopal;Yao, Yongxiu;Nair, Venugopal

作者机构:

关键词: ALV-J;interleukin 6;tumorigenesis;VEGF-A;VEGFR-2;Immunology and Microbiology Section;Immune response;Immunity

期刊名称:ONCOTARGET ( 影响因子:5.168; 五年影响因子:5.312 )

ISSN: 1949-2553

年卷期: 2016 年 7 卷 49 期

页码:

收录情况: SCI

摘要: Avian leukosis virus subgroup J (ALV-J) is an oncogenic virus causing hemangiomas and myeloid tumors in chickens. Interleukin-6 (IL-6) is a multifunctional pro-inflammatory interleukin involved in many types of cancer. We previously demonstrated that IL-6 expression was induced following ALV-J infection in chickens. The aim of this study is to characterize the mechanism by which ALV-J induces IL-6 expression, and the role of IL-6 in tumor development. Our results demonstrate that ALV-J infection increases IL-6 expression in chicken splenocytes, peripheral blood lymphocytes, and vascular endothelial cells. IL-6 production is induced by the ALV-J envelope protein gp85 and capsid protein p27 via PI3K- and NF-kappa B-mediated signaling. IL-6 in turn induced expression of vascular endothelial growth factor (VEGF)-A and its receptor, VEGFR-2, in vascular endothelial cells and embryonic vascular tissues. Suppression of IL-6 using siRNA inhibited the ALV-J induced VEGF-A and VEGFR-2 expression in vascular endothelial cells, indicating that the ALV-J-induced VEGF-A/VEGFR-2 expression is mediated by IL-6. As VEGF-A and VEGFR-2 are important factors in oncogenesis, our findings suggest that ALV-J hijacks IL-6 to promote tumorigenesis, and indicate that IL-6 could potentially serve as a therapeutic target in ALV-J infections.

分类号:

  • 相关文献

[1]Identification and screening of effective protective antigens for channel catfish against Streptococcus iniae. Wang, Yajun,Wang, Erlong,He, Yang,Wang, Kaiyu,Yang, Qian,Wang, Jun,Geng, Yi,Ouyang, Ping,Lai, Weimin,Wang, Yajun,Wang, Kaiyu,Geng, Yi,Chen, Defang,Huang, Xiaoli. 2017

[2]Temporal changes of microRNA gga-let-7b and gga-let-7i expression in chickens challenged with subgroup J avian leukosis virus. Ji, Jun,Ji, Jun,Shang, Huiqin,Li, Hongxin,Ma, Jingyun,Bi, Yingzuo,Xie, Qingmei,Ji, Jun,Shang, Huiqin,Li, Hongxin,Ma, Jingyun,Bi, Yingzuo,Xie, Qingmei,Zhang, Huanmin,Ma, Jingyun,Bi, Yingzuo,Xie, Qingmei,Xie, Qingmei.

[3]Chinese herbs (Astragalus membranaceus and Lonicera japonica) and boron enhance the non-specific immune response of Nile tilapia (Oreochromis niloticus) and resistance against Aeromonas hydrophila. Ardo, Laszlo,Varadi, Laszlo,Jeney, Zsigmond,Jeney, Galina,Yin, Guojun,Xu, Pao,Szigeti, Gabor.

[4]Fusion of C3d with hemagglutinin enhances protective immunity against swine influenza virus. Li, Guo-Xin,Tian, Zhi-Jun,Yu, Hai,Jin, Yuan-Yuan,Hou, Shao-Hua,Zhou, Yan-Jun,Liu, Tian-Qiang,Hu, Shou-Ping,Tong, Guang-Zhi,Li, Guo-Xin,Tong, Guang-Zhi,Li, Guo-Xin,Yu, Hai,Zhou, Yan-Jun,Tong, Guang-Zhi.

[5]Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: Subunit vaccine vs DNA vaccine. Sun, Yun,Sun, Li,Sun, Yun,Liu, Chun-Sheng.

[6]Molecular cloning, characterization and expression analysis of a clip-domain serine protease from pearl oyster Pinctada fucata. Xu, Xinping,Xu, Xinping,Zhang, Dianchang,Jiang, Shigui,Ma, Jianjun,Jiang, Jingjing,Pan, Dequan,Zhang, Dianchang,Jiang, Jingjing.

[7]MicroRNA-497 inhibits thyroid cancer tumor growth and invasion by suppressing BDNF. Wang, Peisong,Meng, Xianying,Liu, Jia,Wang, Guimin,Meng, Wei,Xue, Shuai,Zhang, Qiang,Chen, Guang,Huang, Yan,Lv, Zhi,Zhang, Pengju. 2017

[8]Balancing Between Aging and Cancer: Molecular Genetics Meets Traditional Chinese Medicine. Liu, Jing,Peng, Lei,Huang, Wenhui,Sang, Lei,Lu, Siqian,Zhang, Jihong,Luo, Ying,Li, Zhiming,Pan, Jun,Li, Wanyi,Luo, Ying. 2017

[9]A Tiny RNA that Packs a Big Punch: The Critical Role of a Viral miR-155 Ortholog in Lymphomagenesis in Marek's Disease. Zhuang, Guoqing,Sun, Aijun,Teng, Man,Luo, Jun,Luo, Jun. 2017

[10]Porcine granulin gene (GRN): Molecular cloning, polymorphism and chromosomal localization. Yang, Jine,Yu, Mei,Liu, Bang,Zhu, Mengjin,Li, Kui.

[11]Shikonin causes apoptosis by disrupting intracellular calcium homeostasis and mitochondrial function in human hepatoma cells. Wang, Hui,Liu, Zheng,Wu, Handong,Li, Xiangchen,Zhao, Ruijie,Pu, Yabin,Guan, Weijun. 2018

[12]Knockdown of CDK2AP1 by RNA interference inhibits cell growth and tumorigenesis of human glioma. Xu, Yonggang,Wang, Zhi,Wang, Jie,Fu, Songbin. 2014

[13]Distinct expression pattern of miRNAs in Marek's disease virus infected-chicken splenic tumors and non-tumorous spleen tissues. Li, Zhi-jie,Zhang, Yan-ping,Zheng, Hui-wen,Zheng, Yong-sheng,Liu, Chang-jun,Li, Yang.

[14]Marek's disease virus-encoded microRNAs: genomics, expression and function. Luo Jun,Teng Man,Fan JianMing,Wang FangYu,Zhou Ling,Deng RuiGuang,Zhang GaiPing,Fan JianMing. 2010

[15]Endogenous Retrovirus ev21 Dose Not Recombine with ALV-J and Induces the Expression of ISGs in the Host. Feng, Min,Tan, Yan,Li, Yuanfang,Xie, Tingting,Li, Hongmei,Zhang, Xiquan,Feng, Min,Tan, Yan,Li, Yuanfang,Xie, Tingting,Li, Hongmei,Zhang, Xiquan,Feng, Min,Tan, Yan,Li, Yuanfang,Xie, Tingting,Li, Hongmei,Zhang, Xiquan,Dai, Manman,Shi, Meiqing. 2016

[16]GADD45 beta, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens. Zhang, Xinheng,Yan, Zhuanqiang,Li, Xinjian,Lin, Wencheng,Dai, Zhenkai,Yan, Yiming,Lu, Piaopiao,Chen, Weiguo,Chen, Feng,Ma, Jingyun,Xie, Qingmei,Zhang, Xinheng,Yan, Zhuanqiang,Li, Xinjian,Lin, Wencheng,Dai, Zhenkai,Yan, Yiming,Lu, Piaopiao,Chen, Weiguo,Chen, Feng,Ma, Jingyun,Xie, Qingmei,Zhang, Xinheng,Yan, Zhuanqiang,Li, Xinjian,Lin, Wencheng,Dai, Zhenkai,Yan, Yiming,Lu, Piaopiao,Chen, Weiguo,Chen, Feng,Ma, Jingyun,Xie, Qingmei,Zhang, Xinheng,Li, Xinjian,Lin, Wencheng,Dai, Zhenkai,Yan, Yiming,Lu, Piaopiao,Chen, Weiguo,Chen, Feng,Ma, Jingyun,Xie, Qingmei,Lin, Wencheng,Chen, Weiguo,Chen, Feng,Xie, Qingmei,Zhang, Huanmin. 2016

[17]Innate Immune Responses in ALV-J Infected Chicks and Chickens with Hemangioma In Vivo. Feng, Min,Xie, Tingting,Li, Zhenhui,Zhang, Xiquan,Feng, Min,Xie, Tingting,Li, Zhenhui,Zhang, Xiquan,Feng, Min,Xie, Tingting,Li, Zhenhui,Zhang, Xiquan,Dai, Manman,Shi, Meiqing. 2016

[18]Development of a new duplex real-time polymerase chain reaction assay for detection of dicer in G. gallus. Ji Xiaolin,Wang, Qi,Gao, Yulong,Wang, Yongqiang,Qin, Liting,Qi, Xiaole,Gao, Honglei,Wang, Xiaomei.

[19]NHE1 gene associated with avian leukosis virus subgroup J infection in chicken. Chen, Biao,Pan, Weiling,Zhang, Liangyu,Liu, Jing,Ouyang, Hongjia,Nie, Qinghua,Zhang, Xiquan,Chen, Biao,Pan, Weiling,Zhang, Liangyu,Liu, Jing,Ouyang, Hongjia,Nie, Qinghua,Zhang, Xiquan,Chen, Biao,Pan, Weiling,Zhang, Liangyu,Liu, Jing,Ouyang, Hongjia,Nie, Qinghua,Zhang, Xiquan.

[20]Inhibition of avian leukosis virus subgroup J replication by miRNA targeted against env. Wang, Wei,Zhang, Zai-Ping,Tian, Jin,Xiao, Zhi-Guang,Meng, Qing-Wen.

作者其他论文 更多>>