Avian leukosis virus subgroup J induces VEGF expression via NF-kappa B/PI3K-dependent IL-6 production
文献类型: 外文期刊
第一作者: Gao, Yanni
作者: Gao, Yanni;Zhang, Yao;Guan, Xiaolu;Liu, Yongzhen;Qi, Xiaole;Wang, Yongqiang;Liu, Changjun;Zhang, Yanping;Gao, Honglei;Wang, Xiaomei;Gao, Yulong;Yao, Yongxiu;Nair, Venugopal;Yao, Yongxiu;Nair, Venugopal
作者机构:
关键词: ALV-J;interleukin 6;tumorigenesis;VEGF-A;VEGFR-2;Immunology and Microbiology Section;Immune response;Immunity
期刊名称:ONCOTARGET ( 影响因子:5.168; 五年影响因子:5.312 )
ISSN: 1949-2553
年卷期: 2016 年 7 卷 49 期
页码:
收录情况: SCI
摘要: Avian leukosis virus subgroup J (ALV-J) is an oncogenic virus causing hemangiomas and myeloid tumors in chickens. Interleukin-6 (IL-6) is a multifunctional pro-inflammatory interleukin involved in many types of cancer. We previously demonstrated that IL-6 expression was induced following ALV-J infection in chickens. The aim of this study is to characterize the mechanism by which ALV-J induces IL-6 expression, and the role of IL-6 in tumor development. Our results demonstrate that ALV-J infection increases IL-6 expression in chicken splenocytes, peripheral blood lymphocytes, and vascular endothelial cells. IL-6 production is induced by the ALV-J envelope protein gp85 and capsid protein p27 via PI3K- and NF-kappa B-mediated signaling. IL-6 in turn induced expression of vascular endothelial growth factor (VEGF)-A and its receptor, VEGFR-2, in vascular endothelial cells and embryonic vascular tissues. Suppression of IL-6 using siRNA inhibited the ALV-J induced VEGF-A and VEGFR-2 expression in vascular endothelial cells, indicating that the ALV-J-induced VEGF-A/VEGFR-2 expression is mediated by IL-6. As VEGF-A and VEGFR-2 are important factors in oncogenesis, our findings suggest that ALV-J hijacks IL-6 to promote tumorigenesis, and indicate that IL-6 could potentially serve as a therapeutic target in ALV-J infections.
分类号:
- 相关文献
作者其他论文 更多>>
-
Overexpression of AcWRKY31 Increases Sensitivity to Salt and Drought and Improves Tolerance to Mealybugs in Pineapple
作者:Wai, Myat Hnin;Luo, Tiantian;Zhou, Qiao;Mohammadi, Mohammad Aqa;Cheng, Han;Aslam, Mohammad;Liu, Chang;Chai, Gaifeng;Huang, Dongping;Liu, Yanhui;Cai, Hanyang;Wang, Xiaomei;Qin, Yuan;Wang, Lulu;Wai, Myat Hnin;Luo, Tiantian;Zhou, Qiao;Mohammadi, Mohammad Aqa;Cheng, Han;Aslam, Mohammad;Liu, Chang;Chai, Gaifeng;Huang, Dongping;Liu, Yanhui;Cai, Hanyang;Wang, Xiaomei;Qin, Yuan;Wang, Lulu;Wai, Myat Hnin;Luo, Tiantian;Zhou, Qiao;Mohammadi, Mohammad Aqa;Cheng, Han;Aslam, Mohammad;Liu, Chang;Chai, Gaifeng;Huang, Dongping;Liu, Yanhui;Cai, Hanyang;Wang, Xiaomei;Qin, Yuan;Wang, Lulu;Wai, Myat Hnin;Priyadarshani, S. V. G. N.;Wang, Xiaomei
关键词:pineapple; WRKY transcription factor; AcWRKY31; biotic stress; abiotic stress
-
N123I mutation in the ALV-J receptor-binding domain region enhances viral replication ability by increasing the binding affinity with chNHE1
作者:Yu, Mengmeng;Zhang, Yao;Zhang, Li;Wang, Suyan;Liu, Yongzhen;Xu, Zhuangzhuang;Liu, Peng;Chen, Yuntong;Guo, Ru;Meng, Lingzhai;Zhang, Tao;Fan, Wenrui;Qi, Xiaole;Gao, Li;Zhang, Yanping;Cui, Hongyu;Gao, Yulong;Gao, Yulong;Gao, Yulong
关键词:
-
Improving the function of electrospun film by natural substance for active packaging application of fruits and vegetables
作者:Cui, Xinzhi;Fan, Xinguang;Li, Xiulian;Cui, Xinzhi;Ding, Yibing;Liu, Quanwen;Fan, Xinguang;Ding, Yibing;Sun, Chanchan;Liu, Bangdi;Wang, Xiaomei;Guo, Fengjun
关键词:Electrospinning; Natural bioactive compounds; Active packaging; Submicro-fibers film; Fruit quality
-
OASL suppresses infectious bursal disease virus replication by targeting VP2 for degrading through the autophagy pathway
作者:Wang, Suyan;Xu, Zhuangzhuang;Liu, Yongzhen;Yu, Mengmeng;Zhang, Tao;Liu, Peng;Qi, Xiaole;Chen, Yuntong;Meng, Lingzhai;Guo, Ru;Zhang, Li;Fan, Wenrui;Gao, Li;Duan, Yulu;Zhang, Yanping;Cui, Hongyu;Gao, Yulong;Gao, Yulong;Gao, Yulong;Gao, Yulong
关键词:IBDV; OASL; VP2; degradation; autophagy
-
Integrated analysis of the transcriptome and metabolome reveals the molecular mechanism regulating cotton boll abscission under low light intensity
作者:Zhao, Ning;Geng, Zhao;Zhao, Guiyuan;Liu, Jianguang;An, Zetong;Zhang, Hanshuang;Wang, Yongqiang;Zhao, Ning;Ai, Pengfei
关键词:Cotton; Abscission; Transcriptome; Metabolome; Molecular mechanisms
-
Functional Analysis of the GhIQD1 Gene in Cotton Resistance to Verticillium Wilt
作者:Xu, Jianglin;Wang, Yongqiang;Chen, Quanjia;Zheng, Kai;Xu, Jianglin;Zhou, Ting;Wang, Yongqiang;Yang, Yejun;Sun, Guoqing;Zhou, Ting;Yang, Yejun;Pu, Yuanchun
关键词:cotton; chlorosis; plant hormones; calmodulin-binding protein
-
Investigating the spatiotemporal expression of CBTS genes lead to the discovery of tobacco root as a cembranoid-producing organ
作者:Du, Zaifeng;Tian, Tian;Guan, Jian;Ju, Fuzhu;Bian, Shiquan;Wang, Jiahao;Lin, Xiaoyang;Du, Yongmei;Zhang, Zhongfeng;Zhang, Hongbo;Gao, Yulong;Wang, Bingwu;Liao, Zhihua
关键词:CBTS genes; tobacco; cembranoid; spatiotemporal expression; root