Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses

文献类型： 外文期刊

第一作者： Wang, Wenshuai

作者： Wang, Wenshuai;Zhang, Tianlong;Wang, Fang;Ding, Jianping;Wang, Wenshuai;Zhang, Tianlong;Wang, Fang;Ding, Jianping;Sun, Xiaoyu;Zhang, Hong;Sun, Bing;Li, Yanbing;Chen, Hualan;Su, Jinpeng;Ling, Zhiyang;Sun, Bing;Ding, Jianping

作者机构：

期刊名称：Nature Communications （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2016 年 7 卷

页码：

收录情况： SCI

摘要： As influenza A viruses remain a major threat to human health worldwide, the discovery of broadly neutralizing monoclonal antibodies that recognize conserved epitopes would facilitate the development of antibody-based therapeutic strategies. Here we report that a V(H)4-4-encoded human mAb named 3E1 could neutralize H1 and H5 subtype viruses in vitro and protect mice against the H1N1 and H5N6 viruses by inhibiting the low pH-induced conformational rearrangement of haemagglutinin (HA), hence blocking membrane fusion. The crystal structures of 3E1 Fab in complex with HA of two H1N1 strains reveal that 3E1, with both heavy and light chains, binds to a conserved epitope of the HA stem region, comprising parts of the fusion peptide, the F subdomain and the outermost beta-strand preceding helix A. Altogether, these data suggest the potential of 3E1 as a therapeutic drug against H1 and H5 subtype viruses.

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