Glutamine-induced Secretion of intestinal Secretory immunoglobulin A: A Mechanistic Perspective

文献类型: 外文期刊

第一作者: Ren, Wenkai

作者: Ren, Wenkai;Yin, Jie;Chen, Shuai;Liu, Gang;Tan, Bie;Yin, Yulong;Ren, Wenkai;Yin, Jie;Chen, Shuai;Wang, Kai;Wu, Guoyao;Bazer, Fuller W.;Peng, Yuanyi;Yin, Yulong

作者机构:

关键词: glutamine;intestinal microbiota;secretory IgA;T cells

期刊名称:FRONTIERS IN IMMUNOLOGY ( 影响因子:7.561; 五年影响因子:7.624 )

ISSN: 1664-3224

年卷期: 2016 年 7 卷

页码:

收录情况: SCI

摘要: Secretory immunoglobulin A (SIgA) is one important line of defense in the intestinal mucosal surface to protect the intestinal epithelium from enteric toxins and pathogenic microorganisms. Multiple factors, such as intestinal microbiota, intestinal cytokines, and nutrients are highly involved in production of SIgA in the intestine. Recently, glutamine has been shown to affect intestinal SIgA production; however, the underlying mechanism by which glutamine stimulates secretion of intestinal SIgA is unknown. Here, we review current knowledge regarding glutamine in intestinal immunity and show that glutamine-enhanced secretion of SIgA in the intestine may involve intestinal microbiota, intestinal antigen sampling and presentation, induction pathways for SIgA production by plasma cells (both T-dependent and T-independent pathway), and even transport of SIgA. Altogether, the glutamine-intestinal SIgA axis has broad therapeutic implications for intestinal SIgA-associated diseases, such as celiac disease, allergies, and inflammatory bowel disease.

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