Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host

文献类型： 外文期刊

第一作者： Wang, Shuai

作者： Wang, Shuai;Luo, Xuenong;Dou, Yongxi;Guo, Aijiang;Hou, Junling;Zhang, Shaohua;Meng, Xuelian;Li, Hui;Zhu, Xueliang;Zhu, Xing-quan;Cai, Jianping;Cai, Xuepeng;Wang, Sen;Luo, Yingfeng;Gao, Shenghan;Zhang, Huangkai;Meng, Qingshu;Zhang, Bing;Yang, Meng;Mei, Hailiang;He, Zilong;Tan, Xinyu;Yu, Jun;Hu, Songnian;Wang, Sen;Zhang, Huangkai;Xiao, Lihua;Zhang, Bing;Zhu, Guan

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2016 年 7 卷

页码：

收录情况： SCI

摘要： Taenia saginata, Taenia solium and Taenia asiatica (beef, pork and Asian tapeworms, respectively) are parasitic flatworms of major public health and food safety importance. Among them, T. asiatica is a newly recognized species that split from T. saginata via an intermediate host switch similar to 1.14 Myr ago. Here we report the 169- and 168-Mb draft genomes of T. saginata and T. asiatica. Comparative analysis reveals that high rates of gene duplications and functional diversifications might have partially driven the divergence between T. asiatica and T. saginata. We observe accelerated evolutionary rates, adaptive evolutions in homeostasis regulation, tegument maintenance and lipid uptakes, and differential/specialized gene family expansions in T. asiatica that may favour its hepatotropism in the new intermediate host. We also identify potential targets for developing diagnostic or intervention tools against human tapeworms. These data provide new insights into the evolution of Taenia parasites, particularly the recent speciation of T. asiatica.

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