Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3 alpha/beta Pathway

文献类型： 外文期刊

第一作者： Kong, Ning

作者： Kong, Ning;Wu, Yongguang;Meng, Qiong;Wang, Zhongze;Zuo, Yewen;Pan, Xi;Tong, Wu;Zheng, Hao;Li, Guoxin;Yang, Shen;Yu, Hai;Shan, Tongling;Tong, Guangzhi;Kong, Ning;Tong, Wu;Zheng, Hao;Li, Guoxin;Yu, Hai;Shan, Tongling;Tong, Guangzhi;Kong, Ning;Zhou, En-min;Meng, Qiong

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2016 年 11 卷 8 期

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) has recently caused high mortality in suckling piglets with subsequent large economic losses to the swine industry. Many intracellular signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, are activated by viral infection. The PI3K/Akt pathway is an important cellular pathway that has been shown to be required for virus replication. In the present study, we found that the PEDV JS-2013 strain activated Akt in Vero cells at early (5-15 min) and late stages (8-10 h) of infection. Inhibiting PI3K, an upstream activator of Akt, enhanced PEDV replication. Inhibiting GSK-3 alpha/beta, one of the downstream effectors of PI3K/Akt pathway and regulated by Akt during PEDV infected Vero cells, also enhanced PEDV replication. Collectively, our data suggest that PI3K/Akt/GSK-3 alpha/beta signaling pathway is activated by PEDV and functions in inhibiting PEDV replication.

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