Simple and cost-effective determination of ciprofloxacin hydrochloride by electrical micro-titration

文献类型： 外文期刊

第一作者： Zhang, Xu-Zhi

作者： Zhang, Xu-Zhi;Huang, Meng-Shi;Yang, Qian-Qian;Ding, Dong-Sheng;Zhao, Jun;Qu, Ke-Ming;Huang, Meng-Shi;Yang, Qian-Qian;Yang, Wen-Rong

作者机构：

关键词： Ciprofloxacin hydrochloride;Determination;Micro-titration;Capacitively coupled contactless;conductivity detector;Pharmaceutical analysis

期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：6.779； 五年影响因子：4.558 ）

ISSN： 1001-8417

年卷期： 2017 年 28 卷 7 期

页码：

收录情况： SCI

摘要： By employing an electrical micro-titration system, in which a capacitively coupled contactless conductivity detector ((CD)-D-4) was used to monitor the reaction process in real time, herein a novel method for determining ciprofloxacin hydrochloride (CIPHCI) was developed for the first time. Mode 1: Standard CIPHCI solutions at different concentrations were loaded into reaction cells, respectively, and were titrated with standard Ag+. Upon the titration, the formation of a precipitate alters the number of ions in the solution, raising the change of conductivity, which was monitored by a special (CD)-D-4 to construct a titration curve. The endpoint of the titration was located from the peak of the curve. Between the elapsed time and the initial concentration of titrand, a linear relationship was established over the range of 2.0-8.0 mmol/L. Mode 2: Standard Fe3+ took the place of Ag+, and was used as titrant to recognize ciprofloxacin contributed to the formation of complexation, which also resulting a change of solution conductivity. Under optimized conditions, a working range of 1.0-5.0 mmol/L CIPHCI was found. Because the reaction solutions were isolated from the working electrodes, this pioneer work shows significant simplicity and cost-effectiveness, by eliminating the requirements for detector exchange/renewal between different measurements, and by involving no auxiliary chemicals. Both of the two approaches were applied successfully to determine CIPHCI in tablet samples. And the results were in good agreement with those obtained by reference method. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

分类号：

  • 相关文献

[1]Pseudo template molecularly imprinted polymer for determination of 14 kind of beta-agonists in animal urine by ultra-high-performance liquid chromatography-tandem mass spectrometry. Suo, Decheng,Wang, Ruiguo,Wang, Peilong,Fan, Xia,Su, Xiaoou. 2017

[2]A simple and economic method for simultaneous determination of 11 antibiotics in manure by solid-phase extraction and high-performance liquid chromatography. Feng, Yao,Zhang, Wenjuan,Liu, Yuanwang,Li, Zhaojun,Hu, Haiyan,Wei, Chaojun,Zhang, Wenjuan,Xue, Jianming. 2016

[3]Advance in the Stripping Voltammetry Using Alloy Electrodes for the Determination of Heavy Metal Ions. Zhang, Xuzhi,Qu, Keming,Li, Dongpeng. 2015

[4]Rapid and Sensitive Determination of Dinotefuran Residue Based on Electrochemical Enhancement of beta-cyclodextrin-Graphene Composite. Zhang, M.,Zhai, X. C.,Yang, X.,Zhao, H. T.,Dong, A. J.,Zhang, H.,Wang, J.,Liu, G. Y.,Zhang, M.,Wang, J..

[5]Comparison of Six Methylation Methods for Fatty Acid Determination in Yak Bone Using Gas Chromatography. Jia, Wei,Wu, Ting,Yu, Qunli,Jia, Wei,Liu, Wenyuan,Mi, Si,Zhang, Chunhui,Li, Xia,Wu, Ting,Yu, Qunli,Liu, Wenyuan,Yu, Qunli.

[6]Resonance light-scattering enhancement effect of the protein-Y3+-TTA-SLS system and its analytical application. Guo, Changying,Wu, Xia,Xu, Wei,Yang, Jinghe,Guo, Changying,Wu, Xia,Xu, Wei,Yang, Jinghe,Guo, Changying.

[7]Rapid and simple determination of polyphyllin I, II, VI, and VII in different harvest times of cultivated Paris polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz by UPLC-MS/MS and FT-IR. Wu, Zhe,Zhang, Ji,Wang, Yuanzhong,Zhang, Jinyu,Wu, Zhe,Zhang, Ji,Wang, Yuanzhong,Zhang, Jinyu,Wu, Zhe,Xu, Furong,Zhang, Jinyu.

[8]Miniaturized liquid-liquid extraction coupled with ultra-performance liquid chromatography/tandem mass spectrometry for determination of topramezone in soil, corn, wheat, and water. Dong, Fengshou,Liu, Xingang,Xu, Jun,Li, Jing,Lu, Caihong,Zheng, Yongquan,Wang, Yunhao.

[9]Characterization of Tomato Transcription Factor WUSCHEL and Functional Study in Arabidopsis. Wang Xiang,Wang Xin-guo,Ren Jiang-ping,Ma Ying,Yin Jun,Wang Xiang. 2012

[10]Quantitative determination of soybean meal content in compound feeds: comparison of near-infrared spectroscopy and real-time PCR. Li, Hui,Lv, Xiaowen,Wang, Jing,Li, Junguo,Yang, Haifeng,Qin, Yuchang.

[11]Determination of Major and Trace Elements in Lotus Seed by Inductively Coupled Plasma-Mass Spectrometry. Zhang, Yongzhi,Wang, Gangjun,Ye, Xuezhu,Zheng, Chuangmu.

[12]Determination of Sudan Dyes Residues in the Brine by Liquid Chromatography. Guo, HongBin,Wang, MingYue,Lin, Ling,Yang, ChunLiang,Zhang, LiQiang,Li, Qi,Zeng, RiZhong. 2015

[13]Development of a multi-residue enantiomeric analysis method for 9 pesticides in soil and water by chiral liquid chromatography/tandem mass spectrometry. Dong, Fengshou,Liu, Xingang,Xu, Jun,Chen, Xiu,Han, Yongtao,Liang, Xuyang,Zheng, Yongquan.

[14]Highly sensitive and selective spectrofluorimetric determination of nitrite in food products with a novel fluorogenic probe. Huang, Haiwei,He, Lan,Wang, Qiuhua,Ma, Sufang,Li, Minfeng,Cao, Aocheng.

[15]A RAPID ELECTROCHEMICAL MONITORING PLATFORM FOR SENSITIVE DETERMINATION OF THIAMETHOXAM BASED ON beta-CYCLODEXTRIN-GRAPHENE COMPOSITE. Zhai, Xingchen,Yang, Xin,Wang, Jing,Zhai, Xingchen,Zhang, Hua,Zhang, Min,Yang, Xin,Gu, Cheng,Zhao, Haitian,Wang, Zhenyu,Dong, Aijun,Wang, Jing,Zhou, Guopeng. 2017

[16]Determination of sulfonamides in bovine milk by ultra performance liquid chromatography combined with quadrupole mass spectrometry. She, Yong-Xin,Liu, Jiajia,Wang, Jing,Wang, Rongyan,She, Yong-Xin,Liu, Yong,Cao, Weiqiang.

[17]Ultra-performance convergence chromatography (UPC2) method for the analysis of biogenic amines in fermented foods. Gong, Xiao,Qi, Ningli,Lin, Lijing,Li, Jihua,Wang, Xiaoxi. 2014

[18]Analysis of trace microcystins in vegetables using matrix solid-phase dispersion followed by high performance liquid chromatography triple quadrupole mass spectrometry detection. Qian, Zong-Yao,Li, Zhi-Gang,Ma, Jian,Gong, Ting-Ting,Xian, Qi-Ming,Qian, Zong-Yao.

[19]High Performance Liquid Chromatography determination of Fentin Acetate Residue in Beet and Soil. Sun Hui-qing,Li Yi-qiang,Xu Guang-jun,Zheng Xiao,Xu Jin-li,Wang Xiu-guo. 2012

[20]Determination of Iridoids in Gentiana rigescens by Infrared Spectroscopy and Multivariate Analysis. Qi, Lu-Ming,Qi, Lu-Ming,Zhang, Ji,Zuo, Zhi-Tian,Zhao, Yan-Li,Wang, Yuan-Zhong,Hang, Jin,Qi, Lu-Ming,Zhang, Ji,Zuo, Zhi-Tian,Zhao, Yan-Li,Wang, Yuan-Zhong,Hang, Jin.

作者其他论文 更多>>

微信小程序