Pharmacokinetic/pharmacodynamic relationship of cefquinome against Pasteurella multocida in a tissue- cage model in yellow cattle

文献类型： 外文期刊

第一作者： Shan, Q.

作者： Shan, Q.;Yang, F.;Wang, J.;Ding, H.;He, L.;Zeng, Z.;Shan, Q.;Yang, F.

作者机构：

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期： 2014 年 37 卷 2 期

页码：

收录情况： SCI

摘要： The cephalosporin antimicrobial drug cefquinome was administered to yellow cattle intravenously (i.v.) and intramuscularly (i.m.) at a dose of 1mg/kg of body weight in a two-period crossover study. The pharmacokinetic (PK) properties of cefquinome in serum, inflamed tissue-cage fluid (exudate), and noninflamed tissue-cage fluid (transudate) were studied using a tissue-cage model. The in vitro and ex vivo activities of cefquinome in serum, exudate, and transudate against a pathogenic strain of Pasteurella multocida (P.multocida) were determined. A concentration-independent antimicrobial activity of cefquinome was confirmed for levels lower than 4xMIC. Integration of in vivo pharmacokinetic data with the in vitro MIC provided mean values for the time that drug levels remain above the MIC (T>MIC) in serum was 14.10h after intravenous and 14.46h after intramuscular dosing, indicating a likely high level of effectiveness in clinical infections caused by P.multocida of MIC 0.04g/mL or less. These data may be used as a rational basis for setting dosing schedules, which optimize clinical efficacy and minimize the opportunities for emergence of resistant organisms.

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