Pharmacokinetics and acetylation of sulfamethoxazole in turbot Scophthalmus maximus after intravascular administration

文献类型： 外文期刊

第一作者： Chang Zhiqiang

作者： Chang Zhiqiang;Liu Fei;Lian Chun'ang;Zhai Qianqian;Li Jian;Liu Fei;Lian Chun'ang

作者机构：

关键词： pharmacokinetics;acetylation;sulfamethoxazole;turbot

期刊名称：CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY （ 影响因子：1.068； 五年影响因子：0.983 ）

ISSN： 0254-4059

年卷期： 2016 年 34 卷 4 期

页码：

收录情况： SCI

摘要： The pharmacokinetic profiles and sulfamethoxazole (SMX) acetylation process in turbot reared at 18 degrees C were investigated. Either SMX (parent drug) or its acetylized metabolite, N-4-acetylsulfamethoxazole (AcSMX), was administered intravascularly to turbot at a dosage of 50 mg/kg BW. Serum concentrations of the parent drug and its metabolite were both measured by HPLC, and the changes in concentration over time were analyzed in two-and non-compartment models because SMX treatment produced multiple peaks. The results demonstrated that the elimination half-life of the parent drugs, SMX and AcSMX, were 159.2 and 5.9 h, respectively. The apparent volume of distribution was 0.2 and 0.8 L/kg, and the clearance was 0.038 and 0.222 L/(h.kg), for SMX and AcSMX, respectively. SMX acetylation in turbot was 2.8%, and the deacetylation of AcSMX was 0.2%. These findings may be useful in optimizing SMX dosage regimens in turbot aquaculture.

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