Comparative analysis of alternative splicing events in skeletal muscle of different sheep

文献类型： 外文期刊

第一作者： Miao, Xiangyang

作者： Miao, Xiangyang;Luo, Qingmiao;Zhao, Huijing;Qin, Xiaoyu

作者机构： Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China

关键词： Sheep; Muscle; Alternative splicing; RNA-seq; mRNAs

期刊名称：HELIYON （ 2022影响因子：4.0； 五年影响因子：4.1 ）

ISSN：

年卷期： 2023 年 9 卷 11 期

页码：

收录情况： SCI

摘要： This paper aims to investigate the relationship between genes with alternative splicing (AS) events and breed-specific differences in muscle development in two breeds of sheep. RNA-seq was utilized to identify genes with AS between Small-tailed Han sheep and Dorset sheep. The gene lists of differentially spliced genes were identified, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were conducted on these genes. In this study, 299 genes with 356 AS indicated significant differences between two diffrerent breeds. There are differences in 31 genes with 35 AS. Cassette, alt5 ' and alt3' exhibited the highest levels of enrichment across various significant levels. GO and KEGG enrichment analysis demonstrated a significant correlation between Wnt, TGF-beta, Notch and MAPK signaling pathways and the development of muscle in sheep. These findings indicate that genes with AS are linked to variations in muscle development in sheep. These results offer significant scientific and practical implications for improving the quality of sheep meat.

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