The sweet corn cob selenium polysaccharide alleviates type 2 diabetes via modulation of LPS/IKBα/NFKB and the intestinal microbiota

文献类型： 外文期刊

第一作者： Wang, Jingyang

作者： Wang, Jingyang;Wang, Xin;Xiu, Weiye;Zhou, Zhuo;Yu, Shiyou;Yang, Mengyuan;Ma, Yongqiang;Zhou, Kechi

作者机构：

关键词： Sweet corn cob selenium polysaccharide; Type 2 diabetes; Intestinal barrier; Inflammation; Intestinal microbiota

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.2； 五年影响因子：5.4 ）

ISSN： 2212-4292

年卷期： 2024 年 58 卷

页码：

收录情况： SCI

摘要： Type 2 diabetes (T2D) is a complex metabolic disease characterized by insulin resistance and chronic inflammation. This study explored the effects of sweet corn cob selenium polysaccharide (SeSCP), a complex of selenium and sweet corn cob polysaccharide, on T2D. SeSCP demonstrated significant hypoglycemic effects. This investigation focused on the impact of SeSCP on the intestinal barrier, inflammation, and microbiota in streptozotocin (STZ)-induced T2D mice. These findings revealed that SeSCP effectively reduced blood glucose levels and insulin resistance, decreased intestinal barrier permeability, and modulated the LPS/IKB alpha/NFKB pathway to reduce inflammatory factor production. Additionally, SeSCP corrected intestinal flora imbalances, increasing the relative abundance of Firmicutes in T2D mice. Furthermore, SeSCP enhanced carbohydrate and lipid metabolism in T2D mice, as indicated by Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, demonstrating its potential to alleviate T2D through intestinal modulation.

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