2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8

文献类型： 外文期刊

第一作者： Sun, Dage

作者： Sun, Dage;Kong, Ning;Dong, Sujie;Chen, Xiaoyong;Qin, Wenzhen;Wang, Hua;Jiao, Yajuan;Zhai, Huanjie;Li, Liwei;Gao, Fei;Yu, Lingxue;Zheng, Hao;Tong, Wu;Yu, Hai;Tong, Guangzhi;Shan, Tongling;Kong, Ning;Li, Liwei;Gao, Fei;Yu, Lingxue;Zheng, Hao;Tong, Wu;Yu, Hai;Tong, Guangzhi;Shan, Tongling;Zhang, Wen

作者机构：

关键词： IFN-i; lc3; marchf8; mavs; selective autophagy; sva

期刊名称：AUTOPHAGY （ 影响因子：13.391； 五年影响因子：16.142 ）

ISSN： 1554-8627

年卷期： 2022 年 18 卷 8 期

页码：

收录情况： SCI

摘要： Senecavirus A (SVA), an important emerging porcine virus, has outbreaks in different regions and countries each year, becoming a virus with global prevalence. SVA infection has been reported to induce macroautophagy/autophagy; however, the molecular mechanisms of autophagy induction and the effect of SVA on autophagy remain unknown. This study showed that SVA infection induced the autophagy process in the early stage of SVA infection, and the rapamycin-induced autophagy inhibited SVA replication by degrading virus 3 C protein. To counteract this, SVA utilized 2AB protein inhibiting the autophagy process from promoting viral replication in the late stage of SVA infection. Further study showed that SVA 2AB protein interacted with MARCHF8/MARCH8 and LC3 to degrade the latter and inhibit the autophagy process. In addition, we found that MARCHF8 was a positive regulator of type I IFN (IFN-I) signaling. During the autophagy process, the SVA 2AB protein targeted MARCHF8 and MAVS forming a large complex for degradation to deactivate IFN-I signaling. Together, our study reveals the molecular mechanisms of selective autophagy in the host against viruses and reveals potential viral strategies to evade the autophagic process and IFN-I signaling for successful pathogenesis.

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