Guanylate-Binding Protein 2 Exerts GTPase-Dependent Anti-Ectromelia Virus Effect

文献类型： 外文期刊

第一作者： Gao, Zhenzhen

作者： Gao, Zhenzhen;He, Xiaobing;Chen, Guohua;Fang, Yongxiang;Tian, Huihui;Zhang, Hui;Jing, Zhizhong;Gao, Zhenzhen;He, Xiaobing;Chen, Guohua;Fang, Yongxiang;Tian, Huihui;Zhang, Hui;Jing, Zhizhong;Gao, Zhenzhen;He, Xiaobing;Chen, Guohua;Fang, Yongxiang;Tian, Huihui;Zhang, Hui;Jing, Zhizhong;Meng, Zejing;Jing, Zhizhong

作者机构：

关键词： guanylate binding protein (GBP); IFN-stimulated genes (ISGs); ectromelia virus (ECTV); GTPase

期刊名称：MICROORGANISMS （ 影响因子：4.5； 五年影响因子：4.8 ）

ISSN：

年卷期： 2023 年 11 卷 9 期

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收录情况： SCI

摘要： Guanylate-binding proteins (GBPs) are highly expressed interferon-stimulated genes (ISGs) that play significant roles in protecting against invading pathogens. Although their functions in response to RNA viruses have been extensively investigated, there is limited information available regarding their role in DNA viruses, particularly poxviruses. Ectromelia virus (ECTV), a member of the orthopoxvirus genus, is a large double-stranded DNA virus closely related to the monkeypox virus and variola virus. It has been intensively studied as a highly effective model virus. According to the study, GBP2 overexpression suppresses ECTV replication in a dose-dependent manner, while GBP2 knockdown promotes ECTV infection. Additionally, it was discovered that GBP2 primarily functions through its N-terminal GTPase activity, and the inhibitory effect of GBP2 was disrupted in the GTP-binding-impaired mutant GBP2K51A. This study is the first to demonstrate the inhibitory effect of GBP2 on ECTV, and it offers insights into innovative antiviral strategies.

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