In Vitro Antibacterial and Postantibiotic Effects of Enrofloxacin Combined With Sulfamonomethoxine Against Pathogenic Bacteria of Yellow Catfish (Pelteobagrus fulvidraco)

文献类型： 外文期刊

第一作者： Jia, Bofan

作者： Jia, Bofan;Zhao, Yang;Zhang, Sirong;Deng, Jianchao;Chen, Shengjun;Li, Chunsheng;Huang, Hui;Deng, Yiqin;Xu, Liwen;Qi, Bo;Hu, Xiao;Zhao, Yongqiang;Li, Laihao;Jia, Bofan;Zhao, Yang;Deng, Jianchao

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关键词： antimicrobial; antimicrobial susceptibility testing; drug resistance; PAE duration; synergistic effect

期刊名称：AQUACULTURE RESEARCH （ 影响因子：1.9； 五年影响因子：2.2 ）

ISSN： 1355-557X

年卷期： 2024 年 2024 卷 1 期

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收录情况： SCI

摘要： Research on the synergistic effect of combined antibacterial agents has contributed significantly to addressing microbiological challenges, particularly bacterial resistance mutations. This study employed a combination of enrofloxacin (ENR) and sulfamonomethoxine (SMM) to conduct in vitro antimicrobial susceptibility tests and assess postantibiotic effects (PAEs) against three primary pathogens, Edwardsiella ictaluri, Aeromonas veronii, and Aeromonas hydrophila, known to afflict yellow catfish (Pelteobagrus fulvidraco). The results indicated that the minimum inhibitory concentrations (MICs) of ENR against E. ictaluri, A. veronii, and A. hydrophila were 0.25, 0.125, and 0.125 mu g/mL, respectively. The MICs of SMM against these pathogens were 800, 700, and 700 mu g/mL, respectively. Notably, the combination of ENR and SMM exhibited synergistic effects across all tested strains, increasing the PAE duration compared to ENR or SMM alone at the same concentration (p < 0.05). In addition, the increase in PAE duration and enhanced antibacterial efficacy observed with the ENR-SMM combination demonstrated a positive correlation with the total drug concentration. These results suggest that the combination of ENR and SMM reduced the dosage of individual antibacterial agents while ensuring an efficient antibacterial effect. This approach holds promise for the treatment of bacterial infections in the yellow catfish.

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