Does the activation of sea bass GnIH receptor modulate GnRH receptor signaling?

文献类型： 外文期刊

第一作者： Wang, Bin

作者： Wang, Bin;Wang, Bin;Wang, Bin;Paullada-Salmeron, Jose A.;Verges-Castillo, Alba;Munoz-Cueto, Jose A.;Paullada-Salmeron, Jose A.;Verges-Castillo, Alba;Munoz-Cueto, Jose A.;Paullada-Salmeron, Jose A.;Verges-Castillo, Alba;Munoz-Cueto, Jose A.;Paullada-Salmeron, Jose A.;Verges-Castillo, Alba;Munoz-Cueto, Jose A.

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关键词： GnIH; GnRH; GnIH receptor; GnRH receptor; PKA signaling pathway

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY （ 影响因子：2.1； 五年影响因子：2.2 ）

ISSN： 1095-6433

年卷期： 2024 年 296 卷

页码：

收录情况： SCI

摘要： Previous studies have revealed the stimulatory and inhibitory actions of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH) on the control of reproduction in European sea bass (Dicentrarchus labrax) and other vertebrates, respectively. However, information on the possible interactions between GnRH and GnIH on cell signaling is sparse in vertebrates. In the current study, we investigated if activation of sea bass GnIH receptor (GnIHR) can interfere with GnRH receptor II-1a (GnRHR-II-1a) involving the PKA pathway. Our results showed that GnIH and GnRH functioned via their cognate receptors, respectively. However, it appears that neither GnIH1 nor GnIH2 can block GnRH/GnRHR-II-1a-induced PKA signaling in sea bass. This is the first study to examine the potential interactions of GnIH with GnRH receptor signaling in teleosts. Further research seems necessary to shed light on unknown interactions in other signaling pathways and other GnIH/GnRH receptors involved in the physiological functions of these two relevant neuropeptides, not only in sea bass but also in other species.

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