Synergy between pluripotent stem cell-derived macrophages and self-renewing macrophages: Envisioning a promising avenue for the modelling and cell therapy of infectious diseases

文献类型： 外文期刊

第一作者： Peng, Dingkun

作者： Peng, Dingkun;Li, Meilin;Yao, Meng;Li, Su;Li, Lian-Feng;Qiu, Hua-Ji;Yu, Zhuoran;Yan, Tingsheng;Liu, Zhonghua

作者机构：

关键词： differentiation; infectious diseases; macrophages; pluripotent stem cells; self-renewal

期刊名称：CELL PROLIFERATION （ 影响因子：5.6； 五年影响因子：7.6 ）

ISSN： 0960-7722

年卷期： 2025 年 58 卷 2 期

页码：

收录情况： SCI

摘要： As crucial phagocytes of the innate immune system, macrophages (M phi s) protect mammalian hosts, maintain tissue homeostasis and influence disease pathogenesis. Nonetheless, M phi s are susceptible to various pathogens, including bacteria, viruses and parasites, which cause various infectious diseases, necessitating a deeper understanding of pathogen-M phi interactions and therapeutic insights. Pluripotent stem cells (PSCs) have been efficiently differentiated into PSC-derived M phi s (PSCdM phi s) resembling primary M phi s, advancing the modelling and cell therapy of infectious diseases. However, the mass production of PSCdM phi s, which lack proliferative capacity, relies on large-scale expansions of PSCs, thereby increasing both costs and culture cycles. Notably, M phi s deficient in the MafB/c-Maf genes have been reported to re-enter the cell cycle with the stimulation of specific growth factor cocktails, turning into self-renewing M phi s (SRM phi s). This review summarizes the applications of PSCdM phi s in the modelling and cell therapy of infectious diseases and strategies for establishing SRM phi s. Most importantly, we innovatively propose that PSCs can serve as a gene editing platform to creating PSC-derived SRM phi s (termed PSRM phi s), addressing the resistance of M phi s against genetic manipulation. We discuss the challenges and possible solutions in creating PSRM phi s. In conclusion, this review provides novel insights into the development of physiologically relevant and expandable M phi models, highlighting the enormous potential of PSRM phi s as a promising avenue for the modelling and cell therapy of infectious diseases.

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