Pioneer Transcription Factors: The First Domino in Zygotic Genome Activation

文献类型： 外文期刊

第一作者： Fu, Bo

作者： Fu, Bo;Ma, Hong;Liu, Di;Fu, Bo;Ma, Hong;Liu, Di

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关键词： pioneer transcription factors; preimplantation embryo; zygotic genome activation; retrotransposons

期刊名称：BIOMOLECULES （ 影响因子：4.8； 五年影响因子：5.4 ）

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年卷期： 2024 年 14 卷 6 期

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收录情况： SCI

摘要： Zygotic genome activation (ZGA) is a pivotal event in mammalian embryogenesis, marking the transition from maternal to zygotic control of development. During the ZGA process that is characterized by the intricate cascade of gene expression, who tipped the first domino in a meticulously arranged sequence is a subject of paramount interest. Recently, Dux, Obox and Nr5a2 were identified as pioneer transcription factors that reside at the top of transcriptional hierarchy. Through co-option of retrotransposon elements as hubs for transcriptional activation, these pioneer transcription factors rewire the gene regulatory network, thus initiating ZGA. In this review, we provide a snapshot of the mechanisms underlying the functions of these pioneer transcription factors. We propose that ZGA is the starting point where the embryo's own genome begins to influence development trajectory, therefore in-depth dissecting the functions of pioneer transcription factors during ZGA will form a cornerstone of our understanding for early embryonic development, which will pave the way for advancing our grasp of mammalian developmental biology and optimizing in vitro production (IVP) techniques.

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