Synthesis of Fused pyrazolo[4,3-c]quinolines through KI-Promoted Cyclization of Pyrazole-arylamines and Benzyl Bromide

文献类型： 外文期刊

第一作者： Mu, Yangxiu

作者： Mu, Yangxiu;Iqbal, Zafar;Jiang, Rui;Hou, Jing;Yang, Zhixiang;Tang, Dong;Li, Hongjun

作者机构：

关键词： Pyrazolo[4; 3-c]quinoline; 2-(1H-pyrazol-5-yl)anilines; Benzyl bromide; Potassium iodide; Fused heterocycle

期刊名称：CHEMISTRYSELECT （ 影响因子：2.307； 五年影响因子：2.112 ）

ISSN： 2365-6549

年卷期： 2022 年 7 卷 10 期

页码：

收录情况： SCI

摘要： A simple and highly efficient protocol was developed for the formation of pyrazolo[4,3-c]quinolines starting from 2-(1H-pyrazol-5-yl)anilines and benzyl bromide in the presence of KI, affording desired products in moderate to good yields. The reaction showed good tolerance for a range of substrates with variable substituents. In this methodolgy, benzyl bromide proved to be an available C1 synthon in organic synthesis. Moreover, benzyl bromide can be replaced with benzyl iodide to synthesize pyrazolo[4,3-c]quinoline derivatives, and benzyl chloride could not apply in this reaction system.

分类号：

  • 相关文献
作者其他论文 更多>>
  • Impacts of Conservation Tillage on Agricultural Land Development: A Review

    作者：Liang, Xue;Zhiqi, Wang;Raza, Muhammad Ali;Ma, Zhongming;Rehman, Sana Ur;Raza, Muhammad Ali;Haider, Imran;Khalid, Muhammad Hayder Bin;Saeed, Amjad;Iqbal, Zafar;Fatima, Shroz;Siddiqa, Ayesha;Ansar, Muhammad;Ijaz, Shahzada Sohail

    关键词：Carbon sequestration; Soil health; Mitigation; Tillage; Land development

  • Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response

    作者：Wu, Jing;Lu, Qi;Hou, Jing;Qiu, Yueqin;Tian, Min;Wang, Li;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong;Wu, Jing;Lu, Qi;Hou, Jing;Qiu, Yueqin;Tian, Min;Wang, Li;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong;Wu, Jing;Lu, Qi;Hou, Jing;Qiu, Yueqin;Tian, Min;Wang, Li;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong;Wu, Jing;Lu, Qi;Hou, Jing;Qiu, Yueqin;Tian, Min;Wang, Li;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong

    关键词：Piglets; PRRSV; baicalein; EGFR; MD simulation

  • Effect of Gardeniae Fructus Powder on Growth Performance, Antioxidant Capacity, Intestinal Barrier Function, and Colonic Microbiota of Weaned Piglets

    作者：Liu, Shilong;Ma, Ming;Guo, Shining;Liu, Shilong;Tian, Min;Qiu, Yueqin;Tang, Jiaxi;Hou, Jing;Lu, Qi;Tian, Chaoyang;Ye, Guohao;Wang, Li;Gao, Kaiguo;Jiang, Zongyong;Yang, Xuefen;Liu, Shilong;Tian, Min;Qiu, Yueqin;Tang, Jiaxi;Hou, Jing;Lu, Qi;Tian, Chaoyang;Ye, Guohao;Wang, Li;Gao, Kaiguo;Jiang, Zongyong;Yang, Xuefen;Liu, Shilong;Tian, Min;Qiu, Yueqin;Tang, Jiaxi;Hou, Jing;Lu, Qi;Tian, Chaoyang;Ye, Guohao;Wang, Li;Gao, Kaiguo;Jiang, Zongyong;Yang, Xuefen;Liu, Shilong;Tian, Min;Qiu, Yueqin;Tang, Jiaxi;Hou, Jing;Lu, Qi;Tian, Chaoyang;Ye, Guohao;Wang, Li;Gao, Kaiguo;Jiang, Zongyong;Yang, Xuefen

    关键词：piglet; Gardeniae Fructus; antioxidant capacity; intestinal barrier function; colonic microbiota

  • The agricultural plastic paradox: Feeding more, harming more?

    作者：Wang, Kai;Liu, Xuejun;Zhang, Fusuo;Wang, Kai;Liu, Xuejun;Zhang, Fusuo;Wang, Kai;Liu, Xuejun;Zhang, Fusuo;Chadwick, David R.;Jones, Davey L.;Yan, Changrong;Reay, Michaela;Lloyd, Charlotte;Evershed, Richard P.;Ge, Tida;Ding, Fan;Wang, Jingkuan;Qi, Ruimin;Xiao, Mouliang;Jiang, Rui;Chen, Yanling;Ma, Ji;Luo, Yongming;Zhu, Yongguan

    关键词：Agroecosystem resilience; Plastic pollution; Sustainable development goals; Nanoplastic

  • Unraveling Fish Community Diversity and Structure in the Yellow Sea: Evidence from Environmental DNA Metabarcoding and Bottom Trawling

    作者：Zhang, Jinyong;Liu, Yuan;Ye, Jinqing;Li, Hongjun;Cui, Xiaoyu;Lin, Lin;Zhang, Weiyue

    关键词：eDNA metabarcoding; fish community; diversity; bottom trawling; Yellow Sea

  • Allelic variation in the promoter of WRKY22 enhances humid adaptation of Arabidopsis thaliana

    作者：Liang, Ruyun;Tan, Luna;Guo, Xiang;Lou, Shangling;Dan, Xuming;Han, Yu;Zeng, Cheng;Zhang, Han;Yang, Kai;Chen, Liyang;Liang, Xin;Liu, Meng;Guo, Mengyun;Yin, Kangqun;Tang, Si;Song, Yan;Gao, Xuemeng;Gu, Shaobo;Hou, Jing;Yao, Yingjun;Zhang, Ruijia;Yan, Jin;Fu, Wensen;Li, Xuerui;Hu, Yongqi;Liu, Yao;Liu, Wei;Wu, Qiusai;Yan, Zhen;Wang, Jing;Liu, Jianquan;Liu, Huanhuan;Liang, Ruyun;Tan, Luna;Guo, Xiang;Lou, Shangling;Dan, Xuming;Han, Yu;Zeng, Cheng;Zhang, Han;Yang, Kai;Chen, Liyang;Liang, Xin;Liu, Meng;Guo, Mengyun;Yin, Kangqun;Tang, Si;Song, Yan;Gao, Xuemeng;Gu, Shaobo;Hou, Jing;Yao, Yingjun;Zhang, Ruijia;Yan, Jin;Fu, Wensen;Li, Xuerui;Hu, Yongqi;Liu, Yao;Liu, Wei;Wu, Qiusai;Yan, Zhen;Wang, Jing;Liu, Jianquan;Liu, Huanhuan;Hu, Binhua;Jia, Weitao

    关键词：WRKY22; RAP2.12; WRKY70; ARRs; natural variation; submergence tolerance

  • Ruthenium-catalyzed reaction of dinitriles with primary alcohols for the synthesis of N-alkylated cyclic β-enaminonitriles

    作者：Ma, Wei;Zhao, Qiang;Su, Shibin;Zhang, Weiwei;Yao, Yao;Wang, Pei;Tang, Dong;Zhou, Pengjuan

    关键词：N-alkylated cyclic beta-enaminonitriles; aliphatic dinitrile; primary alcohol; ruthenium-catalyzed

微信小程序