Sc(OTf)3-catalyzed synthesis of polysubstituted furans from acylacetonitriles and renewable acetol

文献类型： 外文期刊

第一作者： Huang, Wenbo

作者： Huang, Wenbo;Liu, Fang;Wang, Kaimei;Zhang, Zhigang;Fang, Wei;Ke, Shaoyong;Huang, Wenbo;Li, Minghao;Gu, Yanlong;Ke, Shaoyong;Sidorenko, Alexander;Gu, Yanlong

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关键词： Acetal [3+2] annulation; Furan; Fenfuram; Antifungal activity

期刊名称：GREEN SYNTHESIS AND CATALYSIS

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年卷期： 2022 年 3 卷 4 期

页码：

收录情况： SCI

摘要： A [3 + 2] cyclization reaction of acylacetonitriles and hydroxyacetone was developed by using Sc(OTf)3 as a catalyst to synthesize some furan derivatives. Bifunctional C2-based acetals, such as & alpha;-bromoacetaldehyde acetal, 1,4-dithiane-2,5-diol and glycolaldehyde diethyl acetal, also reacted readily as alternative counterpart reagents to acylacetonitriles. The established reactions can be used to synthesize a well-known fungicide, fenfuram. Antifungal activity investigation against four common plant funguses indicated that some of the obtained furan products furnish general and high biological activities.

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