Genome-wide association study discovers new QTL and candidate genes on SSC2 associated with total teat number in Large White x Tongcheng crossbred pigs

文献类型： 外文期刊

第一作者： Yang, Qinghua

作者： Yang, Qinghua;Ma, Fang;Yuan, Jiao;Zhang, Qiaoli;Chen, Zhiyi;Shen, Yang;Meng, Xiangge;Li, Songyu;Yuan, Zining;Zhou, Ping;Liu, Bang;Zhou, Xiang;Liu, Bang;Zhou, Xiang;Zhou, Xiang;Zhou, Xiang

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关键词： GWAS; QTL; SSC2; Tongcheng pig; total teat number

期刊名称：ANIMAL GENETICS （ 影响因子：2.1； 五年影响因子：2.5 ）

ISSN： 0268-9146

年卷期： 2025 年 56 卷 4 期

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收录情况： SCI

摘要： Teat number is an economically important trait in pigs because it is relevant to reproduction efficiency and thus production profitability. In this study, a genome-wide association study (GWAS) was performed with genotyping by genome resequencing, which identified six significant SNPs (single nucleotide polymorphisms) on Sus scrofa chromosome 2 (SSC2) and SSC7 for total teat number using 888 Large White x Tongcheng crossbred pigs. The Bayesian fine-mapping further defined two QTL (quantitative trait loci) with locations of 18.32-19.08 and 21.18-22.11 Mb on SSC2, and one QTL spanned an interval of 97.14-97.91 Mb on SSC7, respectively. The first SSC2 QTL region harbors four candidate genes TTC17, API5, miR-129-2 and HSD17B12. The SSC7 QTL region include two reported candidate genes, VRTN and ABCD4. The average teat numbers are 12.42 +/- 1.38, 13.52 +/- 1.10 and 13.87 +/- 1.03 for TT, TA and AA genotypes of rs340400902 on SSC2, respectively. The T allele of rs340400902 on SSC2 in Large White x Tongcheng crossbred pigs was found to originate from Tongcheng pigs. These findings provides SNPs and candidate genes for the genetic improvement of teat number in pigs.

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