文献类型： 外文期刊

第一作者： Sarker, Md Touhiduzzaman

作者： Sarker, Md Touhiduzzaman;Wang, Shenglin;Wang, Shuang;Zhang, Yanan;Jin, Chenglong;Huang, Xuebing;Li, Kaichao;Elokil, Abdelmotaleb;Zheng, Chuntian;Chen, Wei;Sarker, Md Touhiduzzaman;Wang, Shenglin;Wang, Shuang;Zhang, Yanan;Jin, Chenglong;Huang, Xuebing;Li, Kaichao;Elokil, Abdelmotaleb;Zheng, Chuntian;Chen, Wei;Sarker, Md Touhiduzzaman;Wang, Shenglin;Wang, Shuang;Zhang, Yanan;Jin, Chenglong;Huang, Xuebing;Li, Kaichao;Elokil, Abdelmotaleb;Zheng, Chuntian;Chen, Wei;Sarker, Md Touhiduzzaman;Wang, Shenglin;Wang, Shuang;Zhang, Yanan;Jin, Chenglong;Huang, Xuebing;Li, Kaichao;Elokil, Abdelmotaleb;Zheng, Chuntian;Chen, Wei;Sarker, Md Touhiduzzaman;Wang, Shenglin;Wang, Shuang;Zhang, Yanan;Jin, Chenglong;Huang, Xuebing;Li, Kaichao;Elokil, Abdelmotaleb;Zheng, Chuntian;Chen, Wei;Elokil, Abdelmotaleb;Xia, Weiguang;Lv, Yantai

作者机构：

关键词： Antioxidant; Growing layer chicken; Heat stress; Intestine integrity; Sodium butyrate

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.6； 五年影响因子：2.7 ）

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年卷期： 2025 年 21 卷 1 期

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收录情况： SCI

摘要： Background This study was conducted to evaluate the effects of dietary sodium butyrate (SB) supplementation on the antioxidant status, intestinal morphology, functional damage, and barrier integrity of heat-stressed Hy-Line Sonia (HYS) layer chicks. A total of 240 female HYS at 35 days of age with average body weights (415 +/- 35 g) were divided into 6 groups with 10 replicates/group and 4 chickens per replicate. A 2 x 3 factorial design study was performed, including two conditions of ambient temperature (25 degrees C and 35 degrees C) and three dietary levels of SB (0, 0.5, and 1.0 SB g/kg diet). Results HS decreased (P < 0.05) the performance parameters final body weight (FBW), average daily gain (ADG), and average daily feed intake (ADFI), and increased mortality; compared with the HS groups, supplementation with SB decreased mortality. Compared with thermoneutral conditions, the high-temperature conditions significantly decreased (P < 0.05) the thymus, liver, and heart weights, and the relative length of the jejunum, ileum, and cecum, whereas supplementation with 0.5 SB g/kg diet increased (P < 0.05) the weight of the spleen in growing layer chickens. High temperature decreased (P < 0.05) the villus height (VH) and VH/CD ratio, and increased the crypt depth (CD), and supplementation with SB and the T x SB interaction produced greater VH and VH/CD values in the LSB2 and HSB2 groups. SB decreased (P < 0.05) the concentration of serum malondialdehyde (MDA); however, high temperature decreased (P < 0.05) the activities of the catalase (CAT) and glutathione peroxidase (GSH-Px) antioxidant enzymes. The relative mRNA expression levels of the occluding, zonula occludens-1 (ZO-1), claudin-1, and interleukin-10 (IL-10) proteins were downregulated (P < 0.05) at high-temperatures, while that of transforming growth factor-beta (TGF beta) was upregulated. Dietary supplementation decreased the expression of the inflammatory cytokines nuclear factor kappa B (NF-kappa B), transforming growth factor-beta (TGF beta), and interferon-gamma (IFN gamma), and the T x SB interaction decreased TGF beta gene expression in the LSB2 and HSB2 groups compared with that in the other groups of growing layer chickens. Conclusion SB supplementation effectively alleviated HS-induced oxidative stress and structural and functional damage to the intestine in layer chickens in the growing phase.

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