Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies
文献类型： 外文期刊
第一作者： Elfadadny, Ahmed
作者： Elfadadny, Ahmed;Ragab, Rokaia F.;Elfadadny, Ahmed;Ragab, Rokaia F.;AlHarbi, Maha;Badshah, Farhad;Ibanez-Arancibia, Eliana;Ibanez-Arancibia, Eliana;Ibanez-Arancibia, Eliana;De los Rios-Escalante, Patricio R.;Farag, Ahmed;Hendawy, Amin Omar;De los Rios-Escalante, Patricio R.;Aboubakr, Mohamed;Zakai, Shadi A.;Nageeb, Wedad M.
作者机构：
关键词： Pseudomonas aeruginosa; resistance; pathogenicity; virulence; therapy
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）
ISSN：
年卷期： 2024 年 15 卷
页码：
收录情况： SCI
摘要： Pseudomonas aeruginosa, a Gram-negative bacterium, is recognized for its adaptability and opportunistic nature. It poses a substantial challenge in clinical settings due to its complicated antibiotic resistance mechanisms, biofilm formation, and capacity for persistent infections in both animal and human hosts. Recent studies revealed a potential zoonotic transmission of P. aeruginosa between animals, the environment, and human populations which highlights awareness of this microbe. Implementation of the One Health approach, which underscores the connection between human, animal, and environmental health, we aim to offer a comprehensive perspective on the current landscape of P. aeruginosa management. This review presents innovative strategies designed to counteract P. aeruginosa infections. Traditional antibiotics, while effective in many cases, are increasingly compromised by the development of multidrug-resistant strains. Non-antibiotic avenues, such as quorum sensing inhibition, phage therapy, and nanoparticle-based treatments, are emerging as promising alternatives. However, their clinical application encounters obstacles like cost, side effects, and safety concerns. Effectively addressing P. aeruginosa infections necessitates persistent research efforts, advancements in clinical development, and a comprehension of host-pathogen interactions to deal with this resilient pathogen.
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