GenOrigin: A comprehensive protein-coding gene origination database on the evolutionary timescale of life

文献类型： 外文期刊

第一作者： Tong, Yi-Bo

作者： Tong, Yi-Bo;Shi, Meng-Wei;Qian, Sheng Hu;Chen, Yu-Jie;Luo, Zhi-Hui;Tu, Yi-Xuan;Xiong, Yu-Li;Geng, Ying-Jie;Chen, Zhen-Xia;Tong, Yi-Bo;Shi, Meng-Wei;Qian, Sheng Hu;Chen, Yu-Jie;Luo, Zhi-Hui;Tu, Yi-Xuan;Xiong, Yu-Li;Geng, Ying-Jie;Chen, Zhen-Xia;Chen, Chunyan;Chen, Zhen-Xia;Chen, Zhen-Xia;Chen, Zhen-Xia

作者机构：

关键词： Gene age; Gene family; Comparative analysis

期刊名称：JOURNAL OF GENETICS AND GENOMICS （ 影响因子：5.723； 五年影响因子：5.755 ）

ISSN： 1673-8527

年卷期： 2021 年 48 卷 12 期

页码：

收录情况： SCI

摘要： The origination of new genes contributes to the biological diversity of life. New genes may quickly build their network, exert important functions, and generate novel phenotypes. Dating gene age and inferring the origination mechanisms of new genes, like primate-specific genes, is the basis for the functional study of the genes. However, no comprehensive resource of gene age estimates across species is available. Here, we systematically date the age of 9,102,113 protein-coding genes from 565 species in the Ensembl and Ensembl Genomes databases, including 82 bacteria, 57 protists, 134 fungi, 58 plants, 56 metazoa, and 178 vertebrates, using a protein-family-based pipeline with Wagner parsimony algorithm. We also collect gene age estimate data from other studies and uniformly distribute the gene age estimates to time ranges in a million years for comparison across studies. All the data are cataloged into GenOrigin (https://genorigin.chenzxlab.cn/), a user-friendly new database of gene age estimates, where users can browse gene age estimates by species, age, and gene ontology. In GenOrigin, the information such as gene age estimates, annotation, gene ontology, ortholog, and paralog, as well as detailed gene presence/absence views for gene age inference based on the species tree with evolutionary timescale, is provided to researchers for exploring gene functions. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

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