A Peritrophin-44 gene in Litopenaeus vannamei is involved in disease resistance

文献类型： 外文期刊

第一作者： Liu, Li -Shi

作者： Liu, Li -Shi;Fan, Jin-Quan;Zhang, Meng -En;Chen, Qi;Yang, Xin-Jun;Chen, Yi -Hong;Huang, Wen;Chen, Yi -Hong

作者机构：

关键词： Litopenaeus vannamei; Peritrophic membrane; Peritrophin 44; White spot syndrome virus; Unfolded protein response

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：7.7； 五年影响因子：7.7 ）

ISSN： 0141-8130

年卷期： 2024 年 272 卷

页码：

收录情况： SCI

摘要： Peritrophic membrane (PM) is a pellicle structure present in the midgut of some invertebrates, such as insects and crustaceans. It could isolate harmful components and pathogens in food from intestinal epithelial cells; and it also plays a role in improving digestion and absorption efficiency. So PM is important for survival of its owner. In current study, 44 PM proteins were identified in Litopenaeus vannamei by PM proteome analysis. Among these PM proteins, the Peritrophin-44 homologous protein (LvPT44) was further studied. Chitin-binding assay indicated that LvPT44 could bind to colloidal chitin, and immunoeletron microscopy analysis shown that it was located to PM of L. vannamei. Furthermore, LvPT44 promoter was found to be activated by L. vannamei STAT and c-Jun. Besides, LvPT44 was induced by ER-stress as well as white spot syndrome virus infection. Knocked-down expression of LvPT44 by RNA inference increased the cumulative mortality of shrimp that caused by ER-stress or white spot syndrome virus. These results suggested that LvPT44 has an important role in disease resistance.

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