Signatures of selection in tilapia revealed by whole genome resequencing

文献类型： 外文期刊

第一作者： Xia, Jun Hong

作者： Xia, Jun Hong;Liu, Feng;Wan, Zi Yi;Yue, Gen Hua;Xia, Jun Hong;Meng, Zining;Zhang, Yong;Lin, Haoran;Xia, Jun Hong;Meng, Zining;Zhang, Yong;Lin, Haoran;Bai, Zhiyi;Li, Jiale;Jing, Wu;Yue, Gen Hua;Yue, Gen Hua

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2015 年 5 卷

页码：

收录情况： SCI

摘要： Natural selection and selective breeding for genetic improvement have left detectable signatures within the genome of a species. Identification of selection signatures is important in evolutionary biology and for detecting genes that facilitate to accelerate genetic improvement. However, selection signatures, including artificial selection and natural selection, have only been identified at the whole genome level in several genetically improved fish species. Tilapia is one of the most important genetically improved fish species in the world. Using next-generation sequencing, we sequenced the genomes of 47 tilapia individuals. We identified a total of 1.43 million high-quality SNPs and found that the LD block sizes ranged from 10-100 kb in tilapia. We detected over a hundred putative selective sweep regions in each line of tilapia. Most selection signatures were located in non-coding regions of the tilapia genome. The Wnt signaling, gonadotropin-releasing hormone receptor and integrin signaling pathways were under positive selection in all improved tilapia lines. Our study provides a genome-wide map of genetic variation and selection footprints in tilapia, which could be important for genetic studies and accelerating genetic improvement of tilapia.

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