The role of the gut microbial metabolism of sterols and bile acids in human health

文献类型： 外文期刊

第一作者： Tang, Jiahui

作者： Tang, Jiahui;Yu, Yangfan;Yin, Shengxiang;Ye, Bang-Ce;Zhou, Yunyan;Xu, Wenwu

作者机构：

关键词： Gut microbiota; Sterols; Bile acids; Metabolism; Human health

期刊名称：BIOCHIMIE （ 影响因子：3.0； 五年影响因子：3.4 ）

ISSN： 0300-9084

年卷期： 2025 年 230 卷

页码：

收录情况： SCI

摘要： Sterols and bile acids are vital signaling molecules that play key roles in systemic functions, influencing the composition of the human gut microbiota, which maintains a symbiotic relationship with the host. Additionally, gut microbiota-encoded enzymes catalyze the conversion of sterols and bile acids into various metabolites, significantly enhancing their diversity and biological activities. In this review, we focus on the microbial transformations of sterols and bile acids in the gut, summarize the relevant bacteria, genes, and enzymes, and review the relationship between the sterols and bile acids metabolism of gut microbiota and human health. This review contributes to a deeper understanding of the crucial roles of sterols and bile acids metabolism by gut microbiota in human health, offering insights for further investigation into the interactions between gut microbiota and the host. (c) 2024 Elsevier B.V. and Soci & eacute;t & eacute; Fran & ccedil;aise de Biochimie et Biologie Mol & eacute;culaire (SFBBM). All rights are reserved, including those for text and data mining, AI training, and similar technologies.

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